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Long-term outcomes of interventions for radiation-induced xerostomia: A review.

Author: MaSung Jun, RiversCharlotte I, SerraLucas M, SinghAnurag K

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This review of 23 clinical trials evaluates the long-term outcomes of various interventions for radiation-induced xerostomia, a dry mouth condition often experienced by head and neck cancer patients. Pilocarpine, cevimeline, and amifostine were found to improve xerostomia symptoms in some studies, but with potential side effects. ALTENS (acupuncture like transcutaneous electrical nerve stimulation) showed similar efficacy with fewer side effects. Submandibular gland transfer was also effective but requires surgery. Intensity-modulated radiation therapy, combined with dose de-escalation in appropriate patients, may help reduce the incidence of late xerostomia, decreasing the need for further interventions.
Paper Details　
Original Abstract of the Article :
Xerostomia, or dry mouth, is a significant problem affecting quality of life in patients treated with radiation therapy for head and neck cancer. Strategies for reduction of xerostomia burden vary widely, with options including: sialagogue medications, saliva substitutes, acupuncture, vitamins, hype...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318483/

データ提供：米国国立医学図書館（NLM）

Navigating the Desert of Xerostomia: A Camel's Perspective

Radiation therapy, a powerful weapon against cancer, can sometimes leave patients with a parched desert in their mouths – a condition known as xerostomia, or dry mouth. This research delves into the vast landscape of treatment options for radiation-induced xerostomia, seeking to find the most effective strategies to combat this uncomfortable side effect. The authors embark on a journey through the medical literature, analyzing various interventions and evaluating their long-term outcomes.

A Variety of Oasis: Treatments for Xerostomia

The authors present a comprehensive review of treatment options for radiation-induced xerostomia, highlighting the benefits and limitations of each approach. The various options, like oases scattered across a vast desert, offer different degrees of relief and come with varying levels of risk. The authors find that pilocarpine, cevimeline, and amifostine, like sturdy camels, can provide relief for xerostomia, but they may also have associated side effects. Other strategies, such as submandibular gland transfer and acupuncture, offer alternative avenues for addressing xerostomia.

Hydrating the Desert: Finding the Right Solution

This research provides valuable information for clinicians and patients seeking to manage radiation-induced xerostomia. The study's findings underscore the importance of individualized treatment plans, taking into account the patient's needs and preferences. Just as a camel adapts to the arid desert environment, individuals with xerostomia need to find the best strategies to cope with this condition.

Dr. Camel's Conclusion

This review offers a valuable roadmap for navigating the challenging landscape of radiation-induced xerostomia. The authors provide a comprehensive overview of treatment options, highlighting the potential benefits and risks of each approach. Their work emphasizes the importance of individualized treatment plans and the need for ongoing research to develop more effective and less invasive therapies.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-10-05
Further Info :

Pubmed ID

30627521

DOI: Digital Object Identifier

PMC6318483

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・Side Effects of cevimeline
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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