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Effects of CYP2C8 and SLCO1B1 Genetic Polymorphisms on Repaglinide Pharmacokinetics: A Systematic Review and Meta-Analysis.

Author: ChenShuqing, CuiYimin, MaLingyue, MuGuangyan, XiangQian, XieQiufen, ZhangZhuo, ZhouShuang

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Overview

The genotype of CYP2C8, but not SLCO1B1, may affect repaglinide pharmacokinetics. More studies are needed to confirm these findings.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: The purpose of this systematic review and meta-analysis was to summarize the potential impact of CYP2C8 and SLCO1B1 genetic polymorphisms on repaglinide pharmacokinetics. METHODS: A systematic search was conducted using electronic databases. Eligible studies reported data from pharmacoki...See full text at original site
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引用元：
https://doi.org/10.2174/1389200220666190111114146

データ提供：米国国立医学図書館（NLM）

Genetic Polymorphisms and Repaglinide Pharmacokinetics

Repaglinide is a medication used to manage type 2 diabetes by stimulating insulin production. This research explores the impact of genetic variations in two specific genes, CYP2C8 and SLCO1B1, on the pharmacokinetics of repaglinide. The study aims to determine if these genetic variations influence how the body metabolizes and eliminates repaglinide, potentially leading to variations in drug effectiveness.

Genetic Influence on Repaglinide Metabolism

The study reveals that genetic variations in CYP2C8 can influence the pharmacokinetics of repaglinide, while variations in SLCO1B1 do not appear to have a significant impact. The researchers found that individuals with certain CYP2C8 genotypes experience lower levels of repaglinide in their blood, suggesting potential variations in drug efficacy. This finding underscores the need for personalized medicine approaches that consider individual genetic profiles to optimize treatment outcomes.

Personalized Medicine in Diabetes Management

This research highlights the growing importance of personalized medicine in managing chronic conditions like diabetes. Understanding the influence of genetic variations on drug metabolism can help healthcare providers tailor treatment plans to individual needs, potentially leading to more effective and safer outcomes for patients. The study emphasizes the need for further research to investigate the role of genetic testing in diabetes management and to develop personalized treatment strategies based on individual genetic profiles.

Dr.Camel's Conclusion

Like the intricate patterns of sand dunes, genetic variations can have a profound impact on how our bodies respond to medications. This study sheds light on the importance of personalized medicine in diabetes management, reminding us that a one-size-fits-all approach may not always be the most effective. Future research in this area can help us navigate the ever-changing landscape of personalized medicine and create more tailored treatment strategies for individuals with diabetes.

Date :
  1. Date Completed 2019-11-27
  2. Date Revised 2019-11-27
Further Info :

Pubmed ID

30636597

DOI: Digital Object Identifier

10.2174/1389200220666190111114146

Related Literature

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・Effects of repaglinide
SNS
PICO Info
in preparation
Languages

English

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