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Fluoxetine-induced alteration of murine gut microbial community structure: evidence for a microbial endocrinology-based mechanism of action responsible for fluoxetine-induced side effects.
Author: DanielsKarrie M, LyteMark, Schmitz-EsserStephan
Original Abstract of the Article :
Depression and major depressive disorder affect 25% of the population. First line treatment utilizing selective serotonin reuptake inhibitors (SSRIs) have met with limited success due to well-recognized negative side effects which include weight gain or loss. This inability to control unwanted side ...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330042/
データ提供:米国国立医学図書館(NLM)
The Gut Microbiome: A New Frontier in Understanding Antidepressant Side Effects
Depression, like a vast and desolate desert, can be a debilitating condition, affecting millions worldwide. This study, like a team of skilled desert scientists, explores the potential link between the gut microbiome, the complex community of bacteria living in our intestines, and the side effects of fluoxetine, a common antidepressant. The researchers found that fluoxetine, like a carefully curated oasis, altered the structure of the murine gut microbial community, potentially contributing to the development of side effects such as weight gain or loss. This research provides valuable insights into the complex interplay between the gut microbiome and antidepressant medications.
The Gut Microbiome: A Potential Target for Understanding and Treating Antidepressant Side Effects
This research opens up a new frontier in understanding the mechanisms underlying antidepressant side effects, particularly those related to weight changes. The study's findings highlight the importance of considering the gut microbiome as a potential factor in drug response and side effect development.
The Impact on Health and Everyday Life
The study's findings underscore the importance of ongoing research into the complex relationship between the gut microbiome and drug responses. Understanding the role of the gut microbiome in drug efficacy and side effect development could lead to personalized treatment approaches that minimize unwanted side effects and optimize treatment outcomes.
Dr. Camel's Conclusion
This study sheds light on the fascinating world of the gut microbiome, revealing its potential role in shaping drug responses and side effects. The research highlights the importance of considering the gut microbiome as a potential target for optimizing antidepressant treatment and minimizing unwanted side effects.
Date :
- Date Completed n.d.
- Date Revised 2022-03-31
Further Info :
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