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Comparison of cardiovascular effects of crizotinib and chemotherapy in ALK-positive advanced non-small-cell lung cancer.
Author: KimElizabeth E, PolliAnna, UsariTiziana, WilnerKeith D
Original Abstract of the Article :
AIM: We analyzed cardiac function in two Phase III studies of previously treated (PROFILE 1007) or untreated (PROFILE 1014) ALK-positive advanced non-small-cell lung cancer. PATIENTS & METHODS: Adverse events associated with cardiac failure were compared between treatment arms in each study separat...See full text at original site
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引用元:
https://doi.org/10.2217/fon-2018-0869
データ提供:米国国立医学図書館(NLM)
Comparing the Cardiovascular Effects of Crizotinib and Chemotherapy in ALK-Positive Lung Cancer
Navigating the treatment landscape for ALK-positive advanced non-small-cell lung cancer (NSCLC) can feel like traversing a vast desert of options. This research sheds light on the cardiovascular effects of two treatment modalities: crizotinib, a targeted therapy, and traditional chemotherapy. The researchers meticulously compared the cardiac function of patients receiving these treatments, evaluating the potential impact on heart health. This study is particularly relevant due to the potential cardiotoxicity of chemotherapy and the need for safe and effective treatments for ALK-positive NSCLC. This study provides valuable insights into the cardiovascular safety profiles of crizotinib and chemotherapy, offering guidance for clinicians in making informed treatment decisions for patients with ALK-positive NSCLC.
Crizotinib: A Potential Oasis in the Desert of ALK-Positive Lung Cancer Treatment
This research suggests that crizotinib, a targeted therapy, may have a more favorable cardiovascular safety profile compared to chemotherapy in patients with ALK-positive NSCLC. It's like discovering a hidden oasis in the desert of lung cancer treatment, offering a potentially safer and more effective path for patients. The study's findings underscore the importance of considering the cardiovascular safety of treatment options, particularly for patients with pre-existing heart conditions or those at risk for cardiac complications.
Navigating the Desert of Lung Cancer Treatment: Choosing the Right Path
This research provides valuable information for clinicians treating patients with ALK-positive NSCLC. It highlights the importance of individualizing treatment decisions, considering both the efficacy and cardiovascular safety of different therapies. It's like choosing the right path through a desert of treatment options, where a careful assessment of the terrain and potential risks is crucial for a successful journey.
Dr.Camel's Conclusion
This research offers a welcome oasis in the desert of ALK-positive lung cancer treatment. The study's findings highlight the importance of considering the cardiovascular safety of treatment options, particularly for patients with pre-existing heart conditions or those at risk for cardiac complications. As we continue to navigate the vast desert of medical knowledge, studies like this guide us towards a more refined understanding of the potential benefits and risks of various treatments, ultimately improving patient care.
Date :
- Date Completed 2019-08-02
- Date Revised 2019-08-02
Further Info :
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