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The safety of atovaquone-proguanil for the prevention and treatment of malaria in pregnancy: A systematic review.

Author: AndrejkoKristin L, BartlettEmily, GutmanJulie R, KovacsStephanie, MayerRomana C, SlutskerEmma, TanKathrine R

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This systematic review evaluated the safety of atovaquone-proguanil (AP) for malaria prophylaxis during pregnancy. 16 studies were included, suggesting that outcomes after AP exposure during pregnancy are similar to expected rates in similar populations. While AP may be a promising option for pregnant women, further research is needed to confirm its safety in pregnancy.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Malaria infection poses a significant risk in pregnancy, yet chemoprophylaxis for pregnant women is limited. A systematic review was conducted to evaluate the incidence of adverse outcomes after atovaquone-proguanil (AP) exposure during pregnancy. METHODS: Following PRISMA guidelines, t...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/30654041

データ提供：米国国立医学図書館（NLM）

Atovaquone-Proguanil: A Promising Option for Malaria Prevention in Pregnancy

This systematic review evaluates the safety of atovaquone-proguanil (AP) for preventing and treating malaria in pregnancy. The authors recognize the significant risk of malaria infection during pregnancy and the limited options for chemoprophylaxis in this vulnerable population. The review meticulously analyzed a collection of studies, focusing on the incidence of adverse outcomes in pregnant women exposed to AP. The authors sought to provide a comprehensive assessment of AP's safety profile during pregnancy, taking into account both maternal and fetal health.

AP's Safety Profile in Pregnancy: A Promising Outlook

The research revealed that the available data suggest that outcomes following AP exposure during pregnancy are similar to expected rates in comparable populations. This finding is encouraging, suggesting that AP may be a safe and effective option for preventing and treating malaria in pregnancy. The authors acknowledge that further research is needed to solidify AP's safety profile in pregnancy, but the current evidence offers a promising outlook.

Atovaquone-Proguanil: A Hope for Pregnant Women

This systematic review provides valuable insights for healthcare providers seeking to manage malaria in pregnancy. The research highlights the potential benefits of AP, offering a promising option for preventing and treating malaria in this vulnerable population. While further research is needed to definitively establish AP's safety and efficacy, the current evidence offers hope for pregnant women facing the risk of malaria.

Dr.Camel's Conclusion

This systematic review sheds light on the potential of atovaquone-proguanil (AP) as a safe and effective treatment for malaria in pregnancy. The research provides valuable insights for healthcare providers seeking to protect both mothers and their unborn children from the dangers of malaria. The review emphasizes the importance of continued research to solidify AP's safety profile and ensure its widespread availability for pregnant women in malaria-endemic regions.

Date :
  1. Date Completed 2019-04-16
  2. Date Revised 2022-07-16
Further Info :

Pubmed ID

30654041

DOI: Digital Object Identifier

NIHMS1055652

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・Side Effects of atovaquone and proguanil
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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