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Tadalafil treatment in mice for preeclampsia with fetal growth restriction has neuro-benefic effects in offspring through modulating prenatal hypoxic conditions.
Author: EndohMasayuki, FuruhashiFumi, HosodaHiroshi, IkedaTomoaki, IkemuraKenji, KamimotoYuki, KanedaMichiko K, KatoIneko, KimuraTadashi, KondoEiji, MaNing, MagawaShoichi, MakiShintaro, MiyoshiTakekazu, NiiMasafumi, OkudaMasahiro, OwaTakao, ShimadaKyoko, TachibanaRyota, TanakaHiroaki, TanakaKayo, TsujiMakoto, UmekawaTakashi, YoshikawaKento
Original Abstract of the Article :
We have demonstrated that tadalafil facilitates fetal growth in mice with L-NG-nitroarginine methyl ester (L-NAME)-induced preeclampsia (PE) with fetal growth restriction (FGR). Tadalafil is a selective phosphodiesterase 5 inhibitor that dilates the maternal blood sinuses in the placenta, thereby fa...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338749/
データ提供：米国国立医学図書館（NLM）
Tadalafil: A Potential Neuroprotective Agent for Fetuses with Growth Restriction
Preeclampsia (PE) with fetal growth restriction (FGR) is a serious complication of pregnancy, potentially impacting fetal development. This study investigates the neuroprotective effects of tadalafil, a drug known for its ability to dilate blood vessels, in mice with L-NAME-induced PE and FGR. It's like trying to understand how a desert oasis can help a thirsty traveler – we're looking at how tadalafil can potentially protect the fetus from the harsh conditions of PE and FGR.
Tadalafil Improves Fetal Growth and Brain Development
The study found that tadalafil treatment significantly improved fetal growth in mice with PE and FGR. Additionally, it demonstrated neuroprotective effects, potentially enhancing the development of the fetus's brain. This is like a camel caravan finding a hidden oasis, offering a safe haven and ensuring the travelers' well-being. The results suggest that tadalafil might be a promising therapeutic option for PE and FGR.
A New Hope for Infants with Growth Restriction
This study presents encouraging evidence for the potential benefits of tadalafil in managing PE and FGR. It's like discovering a new type of desert plant that can flourish in harsh environments, offering hope and resilience. Further research is needed to confirm these findings and explore the potential of tadalafil as a safe and effective treatment for this challenging condition.
Dr.Camel's Conclusion
This research suggests that tadalafil could be a valuable tool in managing PE and FGR, not only improving fetal growth but also offering neuroprotective benefits for the developing brain. Like a skilled camel guide navigating the vast desert, tadalafil could help pave the way for healthier outcomes for infants facing these complications. It's a promising step towards a brighter future for these vulnerable babies.
Date :
- Date Completed 2020-04-16
- Date Revised 2020-04-16
Further Info :
Related Literature
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