Paper Details 
Original Abstract of the Article :
Genetic polymorphism of thiopurine S-methyltransferase, the key enzyme in metabolism of thiopurines (azathioprine and 6-mercaptopurine) used in the treatment of inflammatory bowel disease, results in different enzyme activities. Decreased enzyme activity causes myelosuppression whereas abnormally hi...See full text at original site
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引用元:
https://doi.org/10.1556/650.2019.31277

データ提供:米国国立医学図書館(NLM)

Thiopurine Treatment: Navigating the Complexities of Metabolism

Thiopurines, a class of medications used to treat inflammatory bowel disease (IBD), are powerful drugs that can have significant effects on the body. They're like a complex desert ecosystem, where every organism plays a crucial role. This research explores the impact of thiopurine treatment on children with IBD, focusing on the importance of genetic variations that influence the metabolism of these drugs. It's like navigating a desert with a map that reveals hidden pathways and potential hazards.

The authors discuss the genetic polymorphism of thiopurine S-methyltransferase (TMPT), an enzyme responsible for breaking down thiopurines. Variations in this enzyme can affect the body's response to thiopurine treatment, leading to either myelosuppression (decreased bone marrow activity) or hepatotoxicity (liver damage). The research highlights the importance of understanding these genetic variations to tailor treatment plans for individual patients, ensuring optimal benefits with minimal risks.

Personalized Medicine: A Tailored Approach to Treatment

This research emphasizes the importance of personalized medicine in managing IBD. By considering the unique genetic makeup of each patient, healthcare professionals can adjust treatment plans to ensure optimal outcomes and reduce the risk of complications. It's like customizing a camel caravan for a specific desert journey, equipping it with the right tools and resources for success.

Navigating the Desert of IBD Treatment

IBD can be a challenging condition to manage, often requiring long-term medication. This research highlights the complexities of thiopurine treatment and the importance of personalized medicine. It's like navigating a vast desert, where understanding the terrain and choosing the right path is crucial for a successful journey. By considering the unique genetic profile of each patient, healthcare professionals can optimize treatment plans and minimize the risk of adverse effects.

Dr.Camel's Conclusion

This research dives deep into the complex world of thiopurine metabolism, highlighting the importance of individual genetic variations. It's like navigating a desert where the landscape changes with every step. By considering these variations, we can tailor treatment plans to each patient, ensuring optimal outcomes and minimizing risks. This research paves the way for a more personalized approach to IBD treatment.

Date :
  1. Date Completed 2019-03-26
  2. Date Revised 2019-03-26
Further Info :

Pubmed ID

30686035

DOI: Digital Object Identifier

10.1556/650.2019.31277

Related Literature

SNS
PICO Info
in preparation
Languages

Hungarian

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