Apomorphine in the treatment of Parkinson's disease: a review.

Author: LeesAndrew J, MoroAdriana, MunhozRenato Puppi, PessoaRenata Ramina, TeiveHélio A G

Paper Details 
Original Abstract of the Article :
Optimizing idiopathic Parkinson's disease treatment is a challenging, multifaceted and continuous process with direct impact on patients' quality of life. The basic tenet of this task entails tailored therapy, allowing for optimal motor function with the fewest adverse effects. Apomorphine, a dopami...See full text at original site
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引用元:
https://doi.org/10.1590/0004-282X20180140

データ提供:米国国立医学図書館(NLM)

Apomorphine: A Hopeful Oasis in the Desert of Parkinson's Disease

The world of Parkinson's disease is a vast and challenging landscape, with symptoms that can be debilitating and life-altering. This study focuses on a potential oasis in this desert, a medication called apomorphine. Apomorphine is a dopamine agonist, a type of drug that mimics the effects of dopamine, a neurotransmitter crucial for motor control. It has been used as rescue therapy for patients experiencing motor fluctuations, those moments when their Parkinson's symptoms worsen. The researchers found that apomorphine can also have positive effects on non-motor symptoms, such as mood and sleep disturbances. The study emphasizes that apomorphine is the only antiparkinsonian agent that can control motor symptoms as effectively as levodopa, a widely used drug for Parkinson's disease. The researchers recommend subcutaneous administration, either through intermittent injections or continuous infusions, as the most effective and well-tolerated method of delivery. This study provides a comprehensive overview of apomorphine, including its history, structure, mechanism of action, indications, contraindications, and side effects. It also compares apomorphine infusion therapy with other treatment options, such as oral therapy, deep brain stimulation, and continuous enteral infusion of levodopa/carbidopa gel. The study concludes with practical instructions on how to initiate treatment with apomorphine.

Apomorphine: A Beacon of Hope in the Treatment of Parkinson's Disease

This research offers a beacon of hope for individuals living with Parkinson's disease. The researchers have found that apomorphine can provide significant relief from motor symptoms and potentially improve non-motor symptoms as well. This study provides valuable information for patients, families, and healthcare professionals seeking effective treatment options for Parkinson's disease.

Navigating the Shifting Sands of Parkinson's Disease

This study provides valuable insights for patients and healthcare professionals navigating the complex world of Parkinson's disease. The researchers emphasize that apomorphine can be a valuable tool for managing symptoms, but it is essential to understand the potential benefits and risks of this medication.

Dr. Camel's Conclusion

Imagine a traveler lost in a vast desert, searching for a source of water and respite. For those with Parkinson's, apomorphine can provide a similar sense of relief, offering a chance to navigate the challenging terrain of their condition. This study serves as a guidepost, highlighting the potential of apomorphine to improve the lives of those affected by Parkinson's disease.

Date :
  1. Date Completed 2019-07-15
  2. Date Revised 2019-07-15
Further Info :

Pubmed ID

30698208

DOI: Digital Object Identifier

10.1590/0004-282X20180140

Related Literature

SNS
PICO Info
in preparation
Languages

English

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