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Cardiac toxicity of combined vemurafenib and cobimetinib administration
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Author: EleftheriouGeorgios, FiocchiRoberto, GalloMariapina, GoriMauro, TaddeiFilippo, TrevisaniLaura

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This case report describes a patient who experienced potentially fatal cardiac side effects, including prolonged QTc interval and reduced left ventricular ejection fraction, after treatment with vemurafenib and cobimetinib for metastatic melanoma. The report highlights the time course of recovery after these side effects, with complete normalization of cardiac function occurring within six months.
Paper Details　
Original Abstract of the Article :
Vemurafenib and cobimetinib are extremely effective in treating V600E-mutated metastatic melanoma, but their use is associated with toxic cardiac effects. Vemurafenib-induced prolonged QTc interval may be associated with ventricular fibrillation and sudden cardiac death. Cobimetinib-induced myocardi...See full text at original site
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引用元：
https://doi.org/10.5414/CP203379

データ提供：米国国立医学図書館（NLM）

Cardiac Toxicity of Vemurafenib and Cobimetinib: A Desert Sandstorm on the Heart

Vemurafenib and cobimetinib, powerful drugs used to treat melanoma, can have significant side effects on the heart. This case report explores the cardiac toxicity of these drugs, highlighting the potential for serious complications. It's like navigating a desert landscape, where a sudden sandstorm can disrupt the delicate balance of the ecosystem.

The case report describes a patient who developed severe cardiac complications after receiving vemurafenib and cobimetinib, including prolonged QTc interval, reduced heart function, and ventricular fibrillation. This highlights the importance of careful monitoring and managing these side effects.

Navigating the Risks

This case report emphasizes the potential cardiac toxicity of vemurafenib and cobimetinib. It's like understanding the dangers of a desert sandstorm, knowing how to prepare and navigate through its destructive force.

Protecting Your Heart

This research highlights the importance of careful monitoring and managing potential side effects of medication. It's like watching for signs of a desert sandstorm, knowing when to take shelter and protect yourself.

Dr.Camel's Conclusion

This case report underscores the importance of careful consideration when treating cancer with vemurafenib and cobimetinib. It's like navigating a treacherous desert, knowing the risks and taking precautions to ensure a safe journey.

Date :
  1. Date Completed 2019-08-05
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

30704555

DOI: Digital Object Identifier

10.5414/CP203379

Related Literature

Article Analysis
・Side Effects of cobimetinib
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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