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High-Density Lipoprotein-Mimicking Nanodiscs for Chemo-immunotherapy against Glioblastoma Multiforme.

Author: AltshulerDavid, CastroMaria G, DohertyRobert, EdwardsMarta, KadiyalaPadma, KamranNeha, KuaiRui, LiDan, LowensteinPedro R, MoonJames J, NuñezFernando M, SchwendemanAnna, YuMinzhi

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the potential of synthetic HDL nanodiscs as a drug delivery platform for treating glioblastoma multiforme (GBM). The study found that delivering docetaxel (DTX) and CpG, a TLR9 agonist, via sHDL nanodiscs to the tumor microenvironment led to tumor regression and antitumor CD8+ T cell responses. Combining this treatment with radiation resulted in long-term survival in 80% of GBM-bearing animals.
Paper Details　
Original Abstract of the Article :
Glioblastoma multiforme (GBM) is an aggressive primary brain tumor, for which there is no cure. Treatment effectiveness for GBM has been limited due to tumor heterogeneity, an immunosuppressive tumor microenvironment (TME), and the presence of the blood-brain barrier, which hampers the transport of ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/30721028

データ提供：米国国立医学図書館（NLM）

Fighting Glioblastoma with Nanodiscs

Glioblastoma multiforme (GBM) is an aggressive form of brain cancer with limited treatment options. This research explores the potential of high-density lipoprotein (HDL)-mimicking nanodiscs as a delivery system for chemo-immunotherapy against GBM. Nanodiscs are tiny structures that can carry drugs and other molecules into cells. The authors designed nanodiscs that mimic HDL, a naturally occurring molecule that transports cholesterol and other substances in the blood. These nanodiscs were loaded with a combination of docetaxel (DTX), a chemotherapy drug, and CpG, an immune stimulant, to target GBM cells. The research found that these nanodiscs were effective in delivering the chemotherapy and immune stimulant to the tumor and eliciting an antitumor response. This study provides promising results for the development of more effective treatments for GBM.

Nanodiscs - A New Weapon in the Fight Against Brain Cancer

This research shows that HDL-mimicking nanodiscs have the potential to revolutionize the treatment of GBM. By delivering a combination of chemotherapy and immunotherapy directly to the tumor, these nanodiscs could overcome the challenges of treating this aggressive cancer. The results of this study suggest that this innovative approach may offer new hope for patients with GBM.

Nanotechnology - A Beacon of Hope in the Desert of Cancer

This research highlights the potential of nanotechnology to advance the fight against cancer. By utilizing nanodiscs to deliver targeted treatments, we may be able to overcome the limitations of traditional chemotherapy and develop more effective therapies for a wide range of cancers. This research is a reminder that with a bit of ingenuity and a focus on innovation, we can find new ways to combat even the most challenging diseases.

Dr. Camel's Conclusion

This research is like a camel caravan trekking across the desert, carrying hope and progress with it. By delivering powerful treatments directly to the tumor, these nanodiscs can act like a beacon of hope in the vast and unforgiving desert of brain cancer. This research is a testament to the power of innovation and the relentless pursuit of better treatments for those facing the challenges of cancer.

Date :
  1. Date Completed 2020-08-03
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

30721028

DOI: Digital Object Identifier

NIHMS1012787

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Languages

English

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