Analyzing the Mechanisms Behind Macrolide Antibiotic-Induced Liver Injury Using Quantitative Systems Toxicology Modeling.

Author: FernandesPrabhavathi, HowellBrett A, MacLauchlinChris, OldachDavid, SilerScott Q, WatkinsPaul B, WoodheadJeffrey L, YangKyunghee

Paper Details 
Original Abstract of the Article :
Macrolide antibiotics are commonly prescribed treatments for drug-resistant bacterial infections; however, many macrolides have been shown to cause liver enzyme elevations and one macrolide, telithromycin, has been pulled from the market by its provider due to liver toxicity. This work seeks to asse...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373306/

データ提供:米国国立医学図書館(NLM)

Unraveling the Mystery of Macrolide Antibiotic-Induced Liver Injury

The use of antibiotics is like a double-edged sword. While they offer a powerful defense against infections, some antibiotics can also cause undesirable side effects. This study explores the mechanisms behind macrolide antibiotic-induced liver injury, venturing into a challenging and complex area of research. This is like exploring a mysterious desert, seeking to uncover the hidden dangers and potential solutions.

The study investigates the mechanisms responsible for the toxicity of macrolide antibiotics, utilizing quantitative systems toxicology modeling. The researchers aim to understand the interplay of factors that contribute to liver injury, providing valuable insights into the potential risks associated with macrolide antibiotics. This research is like mapping a desert, carefully charting the terrain to identify potential pitfalls and navigate safely.

Navigating the Desert of Antibiotic Side Effects

The study highlights the importance of understanding the potential side effects of antibiotics, particularly macrolide antibiotics. This research serves as a reminder that even seemingly beneficial medications can have unintended consequences. This knowledge can guide clinical decisions and help healthcare professionals to select the safest and most effective treatment options for their patients. It’s like having a reliable guidebook in the desert, providing essential knowledge to navigate the complexities of antibiotic therapy.

A Journey of Discovery in Antibiotic Research

This study underscores the ongoing journey of discovery in antibiotic research, seeking to understand the mechanisms of action and potential side effects. The exploration of the complex interplay of factors contributing to macrolide antibiotic-induced liver injury is vital for developing safer and more effective antibiotics. This research is like mapping a new desert, uncovering hidden pathways and valuable knowledge to improve the safety and efficacy of antibiotic therapy.

Dr. Camel's Conclusion

The study provides valuable insights into the potential mechanisms behind macrolide antibiotic-induced liver injury, highlighting the importance of continued research in this area. This knowledge can contribute to the development of safer and more effective antibiotics, leading to better patient care. This journey of discovery is like exploring a vast and intricate desert, seeking to uncover the secrets and mysteries that lie within.

Date :
  1. Date Completed 2019-03-19
  2. Date Revised 2020-04-30
Further Info :

Pubmed ID

30734107

DOI: Digital Object Identifier

PMC6373306

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.