Concerns and Side Effects of Azathioprine During Adalimumab Induction and Maintenance Therapy for Japanese Patients With Crohn's Disease: A Subanalysis of a Prospective Randomised Clinical Trial [DIAMOND Study].

Author: , EsakiMotohiro, HibiToshifumi, HisamatsuTadakazu, IshidaTetsuya, KanaiTakanori, KatoShingo, MatsuiToshiyuki, MatsumotoTakayuki, MotoyaSatoshi, NagahoriMasakazu, NaitoYuji, NakagawaTomoo, NakaseHiroshi, NojimaMasanori, SuzukiYasuo, WatanabeKenji, WatanabeMamoru, YoshimuraNaoki

Paper Details 
Original Abstract of the Article :
Combining a thiopurine with the human anti-tumour necrosis factor-α monoclonal antibody adalimumab for Crohn's disease [CD] treatment is controversial with regard to efficacy and safety. By conducting a subanalysis of a multicentre, randomised, prospective, open-label trial [the DIAMOND study, UMIN ...See full text at original site
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引用元:
https://doi.org/10.1093/ecco-jcc/jjz030

データ提供:米国国立医学図書館(NLM)

A Closer Look at Azathioprine and Adalimumab in Crohn's Disease

This research focuses on the complex interplay of azathioprine and adalimumab in treating Crohn's disease (CD), a chronic inflammatory bowel disease. The study investigates the safety and efficacy of combining these two medications, exploring the potential risks and benefits of this treatment approach. The researchers conducted a subanalysis of a larger clinical trial, examining factors that might influence the discontinuation of thiopurine therapy when used in conjunction with adalimumab. The study highlights the need for careful consideration of the individual patient's needs and potential risks when using this combination therapy.

Navigating the Terrain of Crohn's Disease Treatment

This research delves into the complex landscape of Crohn's disease (CD) treatment, exploring the potential benefits and risks of combining azathioprine and adalimumab. The study emphasizes the need for individualized care, carefully weighing the potential risks and benefits of this combination therapy. It's like navigating a diverse desert landscape, recognizing that different terrain might require different treatment strategies for achieving the desired outcome.

Crohn's Disease: A Chronic Challenge

Crohn's disease (CD) is a chronic inflammatory bowel disease that can significantly impact quality of life. This research highlights the importance of understanding the potential risks and benefits of different treatment options, particularly when combining medications like azathioprine and adalimumab. It's like navigating a complex desert environment, understanding that different approaches might be necessary for achieving optimal health and well-being. Remember, open communication with your healthcare provider is essential for managing Crohn's disease effectively and making informed decisions about your treatment plan.

Dr. Camel's Conclusion

This research examines the safety and efficacy of combining azathioprine and adalimumab in treating Crohn's disease (CD). The study highlights the importance of careful consideration of the individual patient's needs and potential risks when using this combination therapy. It's like navigating a challenging desert landscape, understanding that different terrains may require different strategies for achieving optimal health and well-being.
Date :
  1. Date Completed 2020-02-12
  2. Date Revised 2020-02-12
Further Info :

Pubmed ID

30753377

DOI: Digital Object Identifier

10.1093/ecco-jcc/jjz030

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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