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Acute treatment with the PDE4 inhibitor roflumilast improves verbal word memory in healthy old individuals: a double-blind placebo-controlled study.

Author: BloklandArjan, HeckmanPim R A, LahuGezim, PrickaertsJos, SambethAnke, TsaiMax, UzTolga, Van DuinenMarlies A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigates the acute effects of roflumilast, a phosphodiesterase 4 (PDE4) inhibitor, on memory performance in healthy older adults. The results indicate that roflumilast improved verbal memory performance at a low dose, suggesting potential for developing PDE4 inhibitors for memory enhancement.
Paper Details　
Original Abstract of the Article :
There is ample evidence that phosphodiesterase 4 (PDE4) inhibition can improve memory performance in animal studies. In the present study, we examined the acute effects of the PDE4 inhibitor roflumilast on memory performance in healthy individuals (60-80 years of age). We tested the effects of acute...See full text at original site
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引用元：
https://doi.org/10.1016/j.neurobiolaging.2019.01.014

データ提供：米国国立医学図書館（NLM）

Boosting Memory Power with PDE4 Inhibitors

This study explores the potential of phosphodiesterase 4 (PDE4) inhibitors, a class of drugs that enhance brain function, to improve verbal memory in healthy older adults. The researchers conducted a double-blind, placebo-controlled study with 20 participants aged 60 to 80 years, administering varying doses of roflumilast, a PDE4 inhibitor, or a placebo. The findings revealed that roflumilast at a low dose significantly improved delayed recall performance in a verbal memory test, suggesting its potential as a memory-enhancing agent for older adults.

Roflumilast's Promise for Enhancing Verbal Memory in Older Adults

This study demonstrates the potential of roflumilast, a PDE4 inhibitor, to improve verbal memory in healthy older adults. The researchers observed a significant improvement in delayed recall performance after administering roflumilast at a low dose. This finding suggests that PDE4 inhibitors might offer a promising avenue for addressing age-related cognitive decline and enhancing memory function in older individuals.

Maintaining Cognitive Health: A Lifelong Pursuit

Maintaining cognitive health is a lifelong pursuit. This research highlights the potential of PDE4 inhibitors for enhancing memory function in older adults. However, it's crucial to adopt a holistic approach to brain health, which includes a balanced diet, regular exercise, engaging in mentally stimulating activities, and maintaining a healthy lifestyle. Consulting with a healthcare professional for personalized advice is essential for managing any cognitive concerns.

Dr.Camel's Conclusion

This study, like a camel seeking a hidden oasis of knowledge in the vast desert of the mind, reveals the potential of PDE4 inhibitors to enhance verbal memory in older adults. The researchers' findings offer a glimmer of hope for developing new strategies to combat age-related cognitive decline and preserve memory function, allowing individuals to maintain their mental sharpness throughout their lives.

Date :
  1. Date Completed 2019-12-06
  2. Date Revised 2019-12-17
Further Info :

Pubmed ID

30776650

DOI: Digital Object Identifier

10.1016/j.neurobiolaging.2019.01.014

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PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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