Paper Details

  1. Home
  2. Paper Details

Phase I study of alpha-difluoromethylornithine and methyl-GAG.

Author: RomijnJ C, SplinterT A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The combination of DFMO and MGBG was found to have dose-limiting toxicity, including thrombocytopenia, leucopenia, dyspnea, hemolysis, and jaundice. Continuous administration of DFMO for 8 weeks resulted in hearing loss in 70% of patients, which was reversible. The best-tolerated regimen was continuous administration of DFMO for 21 days and MGBG as a 24-hr infusion on days 7, 14, and 21, repeated on day 42.
Paper Details　
Original Abstract of the Article :
alpha-Difluoromethylornithine (DFMO) is a potent inhibitor of the synthesis of putrescine (pu) and spermidine (sd) in some benign and malignant tissues. Intracellular deprivation of pu and sd has been shown to induce an enhanced uptake of polyamine-analogs such as methyl-GAG (MGBG). The purpose of t...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/0277-5379(86)90343-3

データ提供：米国国立医学図書館（NLM）

Combining DFMO and MGBG: A Promising Strategy for Cancer Treatment

Cancer treatment is a complex and challenging endeavor, with researchers constantly exploring new approaches to improve outcomes. This study investigates the potential of combining alpha-difluoromethylornithine (DFMO) and methyl-GAG (MGBG) to enhance cancer therapy. DFMO is a potent inhibitor of polyamine synthesis, while MGBG is a polyamine analog that can accumulate in cells deprived of polyamines. The authors conducted a phase I clinical trial to assess the safety and efficacy of this drug combination.

Navigating the Desert of Cancer Treatment

The authors meticulously evaluated the safety and efficacy of the DFMO-MGBG combination in patients with various cancers. This research is like navigating a vast and unforgiving desert, searching for a path towards effective cancer treatment. The study found that the combination was well-tolerated, with dose-limiting toxicity primarily related to thrombocytopenia, leucopenia, dyspnea, hemolysis, and jaundice.

Unveiling the Potential of DFMO-MGBG Combination

The study demonstrated that DFMO pretreatment significantly enhanced the toxicity of MGBG, highlighting the importance of carefully managing the combination. Despite the challenges, the authors observed partial remissions in some patients, suggesting the potential of this combination for treating certain cancers. This research, like discovering a hidden oasis in the desert, offers a glimmer of hope for developing novel cancer therapies.

Dr. Camel's Conclusion

This study explores the potential of combining DFMO and MGBG for cancer treatment, highlighting the need for careful dose management to mitigate toxicity. While the combination showed promising results in some patients, further research is needed to optimize its use and identify the most appropriate cancer types for this therapeutic approach. This research, like a journey across a challenging desert landscape, demonstrates the ongoing search for effective and safe cancer treatments.

Date :
  1. Date Completed 1986-04-28
  2. Date Revised 2019-09-08
Further Info :

Pubmed ID

3082642

DOI: Digital Object Identifier

10.1016/0277-5379(86)90343-3

Related Literature

Article Analysis
・Side Effects of eflornithine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.