Plasma concentration and clinical effects of perampanel-The Kork experience.

Author: HübersElisabeth, Jürges Kehl-KorkUta, KurthChristoph, SteinhoffBernhard J

Paper Details 
Original Abstract of the Article :
PURPOSE: To investigate the correlation between steady-state plasma concentrations of perampanel (PER) with efficacy and tolerability in adult patients with difficult-to-treat epilepsy. METHODS: PER plasma concentrations were assessed at steady-state conditions in 92 adult patients (57% female, 43%...See full text at original site
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引用元:
https://doi.org/10.1016/j.seizure.2019.02.022

データ提供:米国国立医学図書館(NLM)

Perampanel Plasma Concentrations and Epilepsy Treatment: A Desert of Complexity

The treatment of epilepsy can be a challenging landscape, like a vast and unforgiving desert. This study delved into the complexities of perampanel, a medication used to treat epilepsy, and aimed to investigate the relationship between steady-state plasma concentrations of perampanel and its efficacy and tolerability in adult patients with difficult-to-treat epilepsy. The researchers sought to identify a potential therapeutic range for perampanel, providing valuable insights for clinicians and patients alike.

The Variability of Perampanel: Navigating the Shifting Sands of Epilepsy Treatment

This research highlights the complexities of treating epilepsy. The study found that perampanel plasma levels and doses varied widely, and there was no clear correlation between plasma levels and clinical outcomes. This highlights the individuality of each patient's response to medication, like the unique patterns of sand dunes in a desert landscape. The study also suggested that therapeutic drug monitoring may still be helpful in certain clinical situations, providing further insights into patient management.

The Importance of Personalized Treatment: Tailoring Therapy to the Individual

This study underscores the importance of personalized treatment approaches for epilepsy. It emphasizes the need to consider individual patient characteristics and response to medication when developing treatment plans. It’s like a camel caravan, navigating a vast desert, where each camel needs specific care and attention to thrive. This research also underscores the need for ongoing research and clinical monitoring to optimize the use of perampanel in epilepsy treatment.

Dr.Camel's Conclusion

This research provides valuable insights into the challenges and complexities of epilepsy treatment. It highlights the importance of personalized medicine and ongoing research to optimize patient care. Navigating the desert of epilepsy treatment requires a deep understanding of the terrain and a commitment to finding the right path for each individual.
Date :
  1. Date Completed 2019-06-18
  2. Date Revised 2021-12-04
Further Info :

Pubmed ID

30852267

DOI: Digital Object Identifier

10.1016/j.seizure.2019.02.022

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English

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