Paper Details

  1. Home
  2. Paper Details

Extracellular Spermine Activates DNA Methyltransferase 3A and 3B.

Author: FukuiTaro, RikiyamaToshiki, SodaKuniyasu, TakaoKoichi

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the effects of extracellular spermine supplementation on gene methylation. Spermine supplementation inhibited adenosylmethionine decarboxylase activity and activated DNA methyltransferases 3A and 3B.
Paper Details　
Original Abstract of the Article :
We first demonstrated that long-term increased polyamine (spermine, spermidine, putrescine) intake elevated blood spermine levels in mice and humans, and lifelong consumption of polyamine-rich chow inhibited aging-associated increase in aberrant DNA methylation, inhibited aging-associated pathologic...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429523/

データ提供：米国国立医学図書館（NLM）

Extracellular Spermine's Role in DNA Methylation: A New Perspective on Aging

This research delves into the complex interplay between [polyamines], [DNA methylation], and [aging]. The study investigates the effects of [extracellular spermine supplementation] on [DNA methyltransferase (DNMT) activity] and [substrate concentrations] involved in DNA methylation. The researchers utilized [cell culture models] to examine the impact of spermine on DNMT activity and the balance of key methylation substrates. This research offers valuable insights into the potential for manipulating polyamine levels to influence DNA methylation patterns and potentially mitigate the effects of aging.

Spermine's Impact on DNMT Activity: A Potential Pathway to Slowing Aging

The study's findings suggest that [extracellular spermine] can directly activate [DNMT 3A and 3B], key enzymes involved in DNA methylation. The researchers observed that spermine supplementation led to [increased DNMT 3A and 3B activity], potentially influencing DNA methylation patterns and potentially impacting the aging process. This study highlights the potential for targeting polyamine metabolism as a strategy for influencing DNA methylation and potentially delaying the onset of age-related conditions.

Navigating the Desert of Aging: Exploring the Roles of Polyamines

This research on spermine and DNA methylation reminds us that the aging process is intricately linked to various cellular processes, including DNA methylation. Just as a desert traveler must learn to adapt to changing conditions, we must seek to understand and manipulate these processes to slow down the effects of aging. This study encourages further research into the role of polyamines in DNA methylation and their potential for influencing the aging process.

Dr. Camel's Conclusion

This research provides valuable insights into the role of extracellular spermine in activating DNMT 3A and 3B, highlighting its potential to influence DNA methylation patterns and potentially impact the aging process. The study encourages further investigation into the complex interplay between polyamines, DNA methylation, and aging.

Date :
  1. Date Completed 2019-06-26
  2. Date Revised 2023-12-13
Further Info :

Pubmed ID

30871110

DOI: Digital Object Identifier

PMC6429523

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.