[Gastrointestinal side effects of apremilast : Characterization and management].

Author: BeigelFlorian, BeissertStefan, GerdesSascha, HomeyBernhard, KörberAndreas, MössnerRotraut, PinterAndreas, RadtkeMarc-Alexander, Staubach-RenzPetra

Paper Details 
Original Abstract of the Article :
Apremilast is an oral inhibitor of phosphodiesterase-4 (PDE4) that is licensed for the second-line treatment of psoriasis and psoriatic arthritis. Data from several phase III clinical trials and real-world studies showed a good benefit-risk profile, with diarrhea and nausea as the most common advers...See full text at original site
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引用元:
https://doi.org/10.1007/s00105-019-4396-6

データ提供:米国国立医学図書館(NLM)

Navigating the Desert of Gastrointestinal Side Effects: Apremilast and Its Implications

The [treatment of psoriasis and psoriatic arthritis] has been transformed by the introduction of [apremilast], an oral inhibitor of phosphodiesterase-4 (PDE4). This research delves into the [gastrointestinal side effects] associated with apremilast. The authors examine data from phase III clinical trials and real-world studies, highlighting diarrhea and nausea as the most common adverse events. The study observes that these gastrointestinal side effects most frequently occur during the first month of treatment, often resolving over time with continued dosing. The research provides practical strategies for managing these symptoms, emphasizing the importance of early intervention and patient education. The authors conclude by emphasizing the need for careful monitoring and proactive management of gastrointestinal side effects to optimize the benefit-risk profile of apremilast.

A Shifting Sandscape: Gastrointestinal Side Effects of Apremilast

This research provides valuable insights into the gastrointestinal side effects associated with apremilast. The study's analysis of clinical trial data and real-world experiences offers a comprehensive understanding of the potential risks and benefits of this medication. The authors' emphasis on the importance of patient education and early intervention highlights the crucial role of proactive management in optimizing treatment outcomes.

A Healthy Journey: Managing Apremilast Side Effects

The research offers practical guidance for patients and healthcare providers seeking to manage the gastrointestinal side effects of apremilast. The study's findings emphasize the importance of open communication, early intervention, and patient education in mitigating the potential risks associated with this medication. The research underscores the importance of a collaborative approach to ensure safe and effective treatment.

Dr.Camel's Conclusion

This research provides a comprehensive overview of the gastrointestinal side effects associated with apremilast, offering valuable insights for patients and healthcare providers. The study emphasizes the importance of proactive management, patient education, and early intervention in optimizing the benefit-risk profile of this medication. The research underscores the need for ongoing research to further refine our understanding of apremilast's effects and develop strategies to minimize the potential for adverse events.

Date :
  1. Date Completed 2019-10-04
  2. Date Revised 2020-02-25
Further Info :

Pubmed ID

30937481

DOI: Digital Object Identifier

10.1007/s00105-019-4396-6

SNS
PICO Info
in preparation
Languages

German

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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