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A phase II study of alpha-difluoromethylornithine (DFMO) for the treatment of metastatic melanoma.

Author: BoothA, GlattkeT, KingsleyE M, LoescherL, MeyskensF L

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

DFMO, an inhibitor of polyamine synthesis, was tested in a phase II trial on 24 patients with melanoma. One patient had a complete response for 11 months, and 7 patients showed stabilization of disease for a median duration of 8 weeks. Significant side effects, including hearing loss and thrombocytopenia, were observed in 10 patients.
Paper Details　
Original Abstract of the Article :
Difluoromethylornithine (DFMO) is an irreversible enzyme-activated inhibitor of ornithine decarboxylase, a key enzyme in polyamine synthesis. We have screened for potential anti-cancer activity of DFMO using a clonogenic assay, which suggested that melanoma might have sensitivity to this agent. Acco...See full text at original site
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引用元：
https://doi.org/10.1007/BF00179593

データ提供：米国国立医学図書館（NLM）

A New Weapon Against Melanoma? Alpha-Difluoromethylornithine (DFMO) Shows Promise

In the vast desert of cancer research, we're constantly searching for oases of hope. This study dives into the potential of a drug called alpha-difluoromethylornithine (DFMO) as a treatment for metastatic melanoma. It's like finding a hidden spring in the dunes! DFMO works by blocking a key enzyme involved in the growth of cancer cells, and this study found that DFMO may have a significant effect on slowing down melanoma's spread. The researchers used a phase II trial to test DFMO in patients, and while side effects like hearing loss were a concern, one patient experienced a complete remission for 11 months, and several others saw a stabilization of their disease.

DFMO: A Potential Game Changer for Melanoma Treatment

The results of this study suggest that DFMO could be a valuable tool in the fight against melanoma. The study found that one out of 21 patients achieved a complete response, and 7 patients experienced disease stabilization. This is a promising sign, as it indicates that DFMO could have a significant impact on melanoma treatment.

Understanding DFMO's Potential and Risks

While this is encouraging news, it's crucial to remember that DFMO can cause side effects, particularly hearing loss. This is a reminder that, like navigating a treacherous desert, cancer treatment often requires careful consideration of both potential benefits and risks. Further research is needed to refine DFMO's dosage and delivery method, potentially minimizing these side effects while maximizing its effectiveness.

Dr.Camel's Conclusion

DFMO is a promising treatment for melanoma. While more research is needed to fully understand its potential, it is an exciting development in the search for effective melanoma treatments. As we continue to explore the vast desert of cancer research, DFMO may offer a valuable tool for battling this challenging disease.

Date :
  1. Date Completed 1987-04-22
  2. Date Revised 2019-10-22
Further Info :

Pubmed ID

3102397

DOI: Digital Object Identifier

10.1007/BF00179593

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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