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The combination of tezacaftor and ivacaftor in the treatment of patients with cystic fibrosis: clinical evidence and future prospects in cystic fibrosis therapy.

Author: LommatzschSherstin T, Taylor-CousarJennifer L

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review discusses the history and current state of cystic fibrosis (CF) treatment, focusing on CFTR protein modulators. CFTR modulators, such as ivacaftor, lumacaftor/ivacaftor, and tezacaftor/ivacaftor, improve CFTR function at the molecular level. Clinicians should be familiar with the side effects of these medications and their impact on patient outcomes.
Paper Details　
Original Abstract of the Article :
Years of tremendous study have dawned a new era for the treatment of cystic fibrosis (CF). For years CF care was rooted in the management of organ dysfunction resulting from the mal-effects of absent anion transport through the CF transmembrane regulator (CFTR) protein. CFTR, an adenosine triphospha...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487765/

データ提供：米国国立医学図書館（NLM）

Tezacaftor and Ivacaftor: A New Era in Cystic Fibrosis Treatment

Cystic fibrosis (CF), a genetic disorder affecting the lungs and other organs, has long been a challenge for researchers and clinicians. This study explores the groundbreaking advancements in CF therapy, focusing on the combination of tezacaftor and ivacaftor, two medications that modulate the function of the CF transmembrane regulator (CFTR) protein. This research highlights the transformative power of scientific innovation in addressing complex genetic diseases.

A Game-Changer for Cystic Fibrosis Patients

The study emphasizes the significant impact of CFTR modulator therapy, particularly the combination of tezacaftor and ivacaftor, on CF patients. These medications work by improving the function of the defective CFTR protein, directly addressing the root cause of the disease. This is a monumental shift in CF treatment, moving beyond symptom management to address the underlying genetic defect. This groundbreaking research has opened a new path for CF patients, offering hope for a healthier and more fulfilling life.

Navigating CF Treatment: A Collaborative Approach

This study underscores the importance of ongoing research and development in CF therapy. It highlights the need for clinicians to stay informed about the latest advancements and to collaborate with patients to develop personalized treatment plans. Just as a camel caravan navigates the desert with careful planning and communication, managing CF requires a coordinated effort between healthcare providers and patients.

Dr.Camel's Conclusion

The combination of tezacaftor and ivacaftor marks a new era in CF treatment. This groundbreaking research has revolutionized our understanding of CF and offers hope for a brighter future for patients with this genetic disorder. It underscores the importance of ongoing research and collaboration between clinicians and patients in navigating the complexities of CF treatment.

Date :
  1. Date Completed 2019-11-15
  2. Date Revised 2020-02-25
Further Info :

Pubmed ID

31027466

DOI: Digital Object Identifier

PMC6487765

SNS
PICO Info
in preparation
Languages

English

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