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Efficacy of oritavancin alone and in combination against vancomycin-susceptible and -resistant enterococci in an in-vivo Galleria mellonella survival model.

Author: DanzigerLarry H, DeraedtMatthew F, HarringtonAmanda T, MeyerKevin A, WenzlerEric

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Oritavancin is a new antibiotic with activity against vancomycin-resistant enterococci (VRE). This study evaluated the efficacy of oritavancin alone and in combination with other antibiotics in a Galleria mellonella model of VRE infection. The study found that oritavancin was effective against both vancomycin-susceptible enterococci and VRE, and that combining oritavancin with other antibiotics could potentially improve treatment outcomes.
Paper Details　
Original Abstract of the Article :
The optimal therapy for serious enterococcal infections, especially vancomycin-resistant enterococci (VRE), remains unclear, although combination therapy is often recommended. Oritavancin has demonstrated in-vitro activity against VRE, but data evaluating oritavancin in combination with other agents...See full text at original site
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引用元：
https://doi.org/10.1016/j.ijantimicag.2019.04.010

データ提供：米国国立医学図書館（NLM）

Oritavancin: A Potential Weapon Against Enterococcal Infections

Infections caused by enterococci, a group of bacteria that can cause serious illness, are a persistent threat to human health. This study delves into the efficacy of oritavancin, a novel antibiotic, against both vancomycin-susceptible and vancomycin-resistant enterococci. The researchers, like brave warriors battling an invisible enemy, sought to evaluate the effectiveness of oritavancin alone and in combination with other antibiotics in an in-vivo Galleria mellonella survival model.

The Power of Oritavancin: A Promising Antibiotic for Enterococcal Infections

The researchers discovered that [研究結果: oritavancin showed promising activity against both vancomycin-susceptible and vancomycin-resistant enterococci, both alone and in combination with other antibiotics]. This study provides valuable insights into the potential of oritavancin as a powerful weapon against enterococcal infections, offering a beacon of hope in the battle against antibiotic resistance.

Combating Antibiotic Resistance: A Global Challenge

The rise of antibiotic resistance is a global threat, akin to a relentless desert sandstorm that threatens to overwhelm our healthcare system. [健康的なベネフィット: Promoting responsible antibiotic use and investing in research and development of new antibiotics] is crucial to combat this growing challenge. It is essential to consult with a healthcare professional for appropriate diagnosis and treatment of infections.

Dr. Camel's Conclusion

This study, a journey through the desert of antibiotic resistance, reveals the potential of oritavancin as a promising weapon against enterococcal infections. The researchers' findings underscore the importance of ongoing research and development of new antibiotics, akin to finding precious water sources in the desert. By working together, we can combat the threat of antibiotic resistance and secure a healthier future for all.

Date :
  1. Date Completed 2019-12-03
  2. Date Revised 2019-12-03
Further Info :

Pubmed ID

31034937

DOI: Digital Object Identifier

10.1016/j.ijantimicag.2019.04.010

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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