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Small intestinal microbial dysbiosis underlies symptoms associated with functional gastrointestinal disorders.

Author: BattaglioliEric J, BeheraGaurav, BerryJonathan C, BhattaraiYogesh, CamilleriMichael, ChenJun, ChoJanice M, FaithJeremiah J, FarrugiaGianrico, GroverMadhusudan, HaleVanessa L, KalariKrishna K, KashyapPurna C, KnightsDan, LekatzHeather R, PatelRobin, PetersStephanie A, SaffouriGeorge B, SchuetzAudrey N, Shields-CutlerRobin R, SonnenburgJustin L, SwannJonathan R, ThompsonKevin J, YangYi

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Small intestinal bacterial overgrowth (SIBO) is a condition where bacteria in the small intestine grow too much. It is thought to contribute to symptoms of functional gastrointestinal disorders (FGIDs), but the exact mechanisms are unknown. This study found that SIBO, as diagnosed by duodenal aspirate culture, does not always correspond with patient symptoms and may be influenced by diet. Instead, changes in the composition of small intestinal microbes were associated with symptoms. A pilot study showed that switching from a high-fiber diet to a low-fiber, high-sugar diet triggered FGID symptoms, reduced microbial diversity, and increased intestinal permeability. These findings suggest that targeting the specific microbial composition of the small intestine may be more effective than general antibiotic treatment for FGIDs.
Paper Details　
Original Abstract of the Article :
Small intestinal bacterial overgrowth (SIBO) has been implicated in symptoms associated with functional gastrointestinal disorders (FGIDs), though mechanisms remain poorly defined and treatment involves non-specific antibiotics. Here we show that SIBO based on duodenal aspirate culture reflects an o...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494866/

データ提供：米国国立医学図書館（NLM）

Microbial Dysbiosis in the Small Intestine: Unraveling the Mysteries of Functional Gastrointestinal Disorders

In the vast and often enigmatic world of gut health, researchers are constantly seeking to understand the complex interplay between the microbiome and digestive disorders. This study delves into the intriguing role of small intestinal microbial dysbiosis in the development of functional gastrointestinal disorders (FGIDs), exploring the potential for a more targeted approach to treatment.

A Microbiome Perspective: Shifting Focus from Overgrowth to Composition

The authors challenge the conventional view of small intestinal bacterial overgrowth (SIBO) as a key factor in FGID symptoms. They argue that, instead of simply focusing on overgrowth, we should consider the specific composition of the small intestinal microbiome. This shift in focus, like a change in desert winds, offers a new perspective on the pathogenesis of FGIDs.

A Pilot Intervention: Unveiling the Influence of Diet on Gut Microbiota

The authors conducted a pilot interventional study, demonstrating a link between dietary changes, small intestinal microbial diversity, and FGID-related symptoms. This finding, like a hidden oasis in the desert of gut health research, highlights the crucial role of diet in shaping the gut microbiome and influencing digestive well-being.

Dr.Camel's Conclusion

This study, like a compass navigating the vast desert of gut health research, points towards a new understanding of FGIDs. It suggests that focusing on the specific composition of the small intestinal microbiome, rather than simply overgrowth, may lead to more effective treatment strategies, potentially including personalized dietary interventions.

Date :
  1. Date Completed 2019-06-06
  2. Date Revised 2023-06-18
Further Info :

Pubmed ID

31043597

DOI: Digital Object Identifier

PMC6494866

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English

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