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Hemorrhagic diathesis and bone marrow aplasia secondary to lomustine overdose in a dog.

Author: BandinelliMarcele B, BianchiSimone P, HenkerLuan C, KemperRegina T, PavariniSaulo P

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Overview

This report describes a fatal case of lomustine overdose in a dog. The dog, mistakenly administered a significantly higher dose of lomustine, developed severe thrombocytopenia and leukopenia, leading to multifocal hemorrhages and bone marrow aplasia.
Paper Details　
Original Abstract of the Article :
A 9-year-old mixed breed 13 kg spayed female dog was presented for evaluation of two masses in the right abdominal mammary gland region. Surgery was conducted to excise the masses. A grade I complex mammary gland carcinoma and high grade (grade III) mast cell tumor with an inguinal lymph node m...See full text at original site
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引用元：
https://doi.org/10.1111/vcp.12734

データ提供：米国国立医学図書館（NLM）

Lomustine Overdose: A Fatal Journey Through a Medical Desert

Lomustine, a chemotherapy drug, is a powerful tool in the fight against cancer, but like a desert oasis, it can be both beneficial and dangerous. This case report describes a fatal case of lomustine overdose in a dog, highlighting the potentially devastating consequences of exceeding therapeutic dosages. The authors document the clinical, hematologic, gross, and histologic findings in this tragic case, emphasizing the need for meticulous attention to drug administration and careful monitoring of patients receiving chemotherapy.

The Dangers of Overdose: A Cautionary Tale

This case report serves as a stark reminder of the potential dangers of drug overdose, even with medications that are often lifesaving. The tragic outcome of this case underscores the importance of careful drug administration, accurate dosage calculations, and close monitoring of patients receiving chemotherapy.

Navigating the Desert of Chemotherapy

Chemotherapy is a powerful tool in the fight against cancer, but it can also be a perilous journey through a medical desert. This case report highlights the importance of vigilance and meticulous attention to detail, emphasizing the need for close monitoring and adherence to prescribed dosages to ensure patient safety and maximize the effectiveness of treatment.

Dr.Camel's Conclusion

Chemotherapy, while a powerful weapon in the fight against cancer, is like a desert oasis – offering potential for healing but also carrying inherent risks. This case report reminds us of the importance of careful drug administration, vigilant monitoring, and a commitment to patient safety. The journey through the desert of chemotherapy requires a steadfast commitment to evidence-based practices and a deep respect for the power of medicine.
Date :
  1. Date Completed 2019-11-11
  2. Date Revised 2019-11-11
Further Info :

Pubmed ID

31062418

DOI: Digital Object Identifier

10.1111/vcp.12734

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Article Analysis
・Effects of lomustine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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