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Dipyridamole inhibits α-amylase/α-glucosidase at sub-micromolar concentrations; in-vitro, in-vivo and theoretical studies.

Author: AzizianSarwar, EsmaeiliSajjad, KhodarahmiReza, MoradiSajad, ShahlaeiMohsen, ShahmoradiBahareh

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Dipyridamole (DP), a drug used to dilate blood vessels, was found to inhibit the activity of α-amylase and α-glucosidase, enzymes involved in glucose absorption. In vivo studies showed a decrease in blood glucose levels after DP administration, suggesting a potential link between DP's clinical effects and its enzyme inhibition properties.
Paper Details　
Original Abstract of the Article :
Dipyridamole (DP) elevates cyclic Adenosine Monophosphate (cAMP) levels in platelets, erythrocytes, and endothelial cells and also blocks adenosine reuptake. It is used to dilate blood vessels in people with peripheral arterial disease and coronary artery disease (CAD). The flexible backbone, hydrop...See full text at original site
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引用元：
https://doi.org/10.1016/j.bioorg.2019.102972

データ提供：米国国立医学図書館（NLM）

Dipyridamole: A Multifaceted Drug with Potential Benefits for Diabetes and Cardiovascular Health

Dipyridamole, like a versatile tool in a doctor's kit, has long been used to dilate blood vessels and improve blood flow in patients with peripheral arterial disease and coronary artery disease (CAD). This study explores the unexpected potential of dipyridamole as a novel inhibitor of alpha-amylase and alpha-glucosidase, enzymes that play a crucial role in regulating blood sugar levels. The researchers carefully investigated dipyridamole's ability to inhibit these enzymes, using a combination of in vitro, in vivo, and theoretical studies. The study's findings reveal dipyridamole's surprising ability to inhibit alpha-amylase and alpha-glucosidase, effectively slowing down the breakdown of carbohydrates and reducing blood sugar levels. This discovery opens up new avenues for research and potential applications for dipyridamole in managing diabetes and related conditions.

A Hidden Talent: Dipyridamole's Potential for Blood Sugar Control

This study unveils a hidden talent of dipyridamole, like a surprising oasis in the desert. Its ability to inhibit alpha-amylase and alpha-glucosidase suggests a potential new role for this drug in managing diabetes and cardiovascular health.

Exploring New Horizons in Diabetes Management

This study encourages further research to explore the potential of dipyridamole as a novel approach to diabetes management. Its ability to inhibit alpha-amylase and alpha-glucosidase, like a gentle desert breeze, could offer a new path toward improving blood sugar control and reducing the risks associated with diabetes.

Dr. Camel's Conclusion

Dipyridamole, like a wise and experienced camel guide, has proven to be a valuable tool in treating cardiovascular diseases. This study reveals a surprising new facet of its potential, suggesting that it could also play a role in managing diabetes. This discovery opens up exciting new avenues for research, potentially leading to innovative treatment strategies for this prevalent condition.

Date :
  1. Date Completed 2020-09-22
  2. Date Revised 2020-09-22
Further Info :

Pubmed ID

31078769

DOI: Digital Object Identifier

10.1016/j.bioorg.2019.102972

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Languages

English

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