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DFMO and 5-Azacytidine Increase M1 Macrophages in the Tumor Microenvironment of Murine Ovarian Cancer.

Author: BachmanKurtis E, BaylinStephen B, BrownStephen M, CaseroRobert A, DunworthMatthew, FoleyJackson R, HolbertCassandra E, StoneMeredith L, TraversMeghan, WiehagenKarla R, ZahnowCynthia A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A combination therapy of 5-Azacytidine (5AZA-C) and α-difluoromethylornithine (DFMO) significantly increased survival and decreased tumor burden in an immunocompetent mouse model for ovarian cancer. This therapy led to a striking increase in activated T cells and NK cells and a decrease in immunosuppressive macrophages, suggesting that it modifies macrophage polarization in the tumor microenvironment.
Paper Details　
Original Abstract of the Article :
Although ovarian cancer has a low incidence rate, it remains the most deadly gynecologic malignancy. Previous work has demonstrated that the DNMTi 5-Azacytidine (5AZA-C) activates type I interferon signaling to increase IFN&#947;<sup>+</sup> T cells and natural killer (NK) cells and reduce the perce...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/31088836

データ提供：米国国立医学図書館（NLM）

Fighting Ovarian Cancer with Epigenetic Therapy and Polyamine Reduction

Ovarian cancer, a serious gynecologic malignancy, poses a significant challenge to healthcare professionals. This research investigates the potential of combining epigenetic therapy with a polyamine-reducing agent to improve outcomes for ovarian cancer patients. It's like combining two powerful forces to fight a formidable enemy.

The study found that a combination of 5-azacytidine (5AZA-C) and DFMO, an ornithine decarboxylase inhibitor, significantly increased survival and reduced tumor burden in an ovarian cancer mouse model. It's like discovering a potent weapon that can effectively target and destroy the enemy's defenses.

A Promising Combination for Ovarian Cancer Treatment

The research suggests that the combination of epigenetic therapy and polyamine reduction may be a promising approach for treating ovarian cancer, offering a potential new avenue for improving patient outcomes. It's like finding a new oasis in a vast desert, providing hope and nourishment to those in need.

Understanding the Role of Macrophages in Ovarian Cancer

The study's findings highlight the importance of macrophage polarization in the tumor microenvironment and its role in determining the efficacy of treatment. It's like understanding the different types of troops in an army, recognizing their strengths and weaknesses to optimize battle strategies.

Dr. Camel's Conclusion

This research offers a glimpse into the potential of combining epigenetic therapy with polyamine reduction to improve outcomes in ovarian cancer. It's like uncovering a hidden treasure chest filled with potent weapons that can effectively fight this formidable disease. This study provides a foundation for future research to explore the potential of this combination therapy.

Date :
  1. Date Completed 2020-04-06
  2. Date Revised 2020-11-26
Further Info :

Pubmed ID

31088836

DOI: Digital Object Identifier

NIHMS1529293

Related Literature

Article Analysis
・Effects of eflornithine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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