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N-acetyltransferase: the practical consequences of polymorphic activity in man.

Author: MitchellStephen C

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Individuals with the 'slow acetylator' phenotype have an increased risk of developing drug side effects, including hepatotoxicity, peripheral neuropathy, and lupus-like symptoms. They also have a higher risk of developing bladder cancer when exposed to arylamines. Conversely, 'rapid acetylators' may have a slightly increased risk of developing pancreatic tumors. The impact of polymorphic N-acetylation on the efficacy and toxicity of other therapeutic agents remains unclear.
Paper Details　
Original Abstract of the Article :
Over the years, numerous studies have supported the premise that individuals possessing the "slow acetylator" phenotype are more at risk from developing drug side-effects. Most prominent amongst these reports are those concerned with hepatotoxicity and peripheral neuropathy following treatment with ...See full text at original site
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引用元：
https://doi.org/10.1080/00498254.2019.1618511

データ提供：米国国立医学図書館（NLM）

The Acetylation Enigma: Exploring the Individuality of Drug Metabolism

The field of pharmacogenomics investigates how individual genetic differences influence our response to drugs. This research focuses on the N-acetyltransferase enzyme, a key player in drug metabolism. It explores the phenomenon of polymorphic activity, where individuals exhibit distinct metabolic rates, impacting their susceptibility to drug side effects. The authors uncover a fascinating link between N-acetylation and the risk of developing various adverse reactions and even certain cancers, highlighting the importance of personalized medicine.

A Tale of Two Acetylators: Slow vs. Rapid

The authors meticulously delve into the world of 'slow' and 'rapid' acetylators, illustrating how genetic variations in N-acetyltransferase influence drug metabolism. They reveal that slow acetylators are more prone to developing drug-related side effects, such as hepatotoxicity and peripheral neuropathy. Conversely, rapid acetylators seem to have a slightly increased risk of pancreatic tumors. This research highlights the complex interplay between genetics, drug metabolism, and individual responses to treatment.

Personalized Medicine: A Desert Oasis in the World of Drug Therapy

This research points to the growing importance of personalized medicine in tailoring drug therapies to individual patients. Understanding a patient's genetic makeup and metabolic profile can help guide treatment decisions and minimize the risk of adverse reactions. As a researcher, I believe that this approach is crucial for maximizing the efficacy of medications and ensuring patient safety.

Dr.Camel's Conclusion

This research underscores the importance of considering individual genetic variations in drug metabolism. The authors' findings highlight the need for a personalized approach to drug therapy to ensure safe and effective treatment. We are now entering an era of personalized medicine, where tailoring treatments to the unique needs of each patient is crucial for improving health outcomes.
Date :
  1. Date Completed 2020-02-20
  2. Date Revised 2020-02-20
Further Info :

Pubmed ID

31092097

DOI: Digital Object Identifier

10.1080/00498254.2019.1618511

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