Pomalidomide, bortezomib, and dexamethasone for patients with relapsed or refractory multiple myeloma previously treated with lenalidomide (OPTIMISMM): a randomised, open-label, phase 3 trial.

Author: , AndersonKenneth, BeksacMeral, BensmaineAmine, BiyukovTsvetan, DimopoulosMeletios, DoerrThomas, FaconThierry, GalliMonica, LiberatiAnna Marina, LindsayJindriska, O'GormanPeter, OriolAlbert, PelusoTeresa, RichardsonPaul G, RobakPawel, San MiguelJesus, ScheySteve, SchjesvoldFredrik, SemochkinSergey, SonneveldPieter, SunamiKazutaka, WeiselKatja, WhiteDarrell, YuXin, ZakiMohamed

Paper Details 
Original Abstract of the Article :
As lenalidomide becomes increasingly established for upfront treatment of multiple myeloma, patients refractory to this drug represent a population with an unmet need. The combination of pomalidomide, bortezomib, and dexamethasone has shown promising results in phase 1/2 trials of patients with rela...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1016/S1470-2045(19)30152-4

データ提供:米国国立医学図書館(NLM)

A Novel Treatment Regimen for Relapsed Multiple Myeloma: Pomalidomide, Bortezomib, and Dexamethasone

The field of [hematology] is dedicated to understanding and treating blood disorders. This research explores a novel treatment regimen for relapsed or refractory multiple myeloma, a type of cancer affecting plasma cells. The authors conducted a randomized, open-label, phase 3 trial to evaluate the efficacy and safety of a combination therapy involving pomalidomide, bortezomib, and dexamethasone in patients previously treated with lenalidomide. The study found that this triplet regimen showed promising results in terms of response rates and overall survival, offering a potential treatment option for patients with lenalidomide-refractory multiple myeloma. The study highlights the potential benefits of this new treatment regimen for a challenging patient population.

A New Hope for Relapsed Multiple Myeloma: A Triplet Regimen Showcases Promise

The promising results of this phase 3 trial suggest that the combination of pomalidomide, bortezomib, and dexamethasone may offer a new and effective treatment option for patients with lenalidomide-refractory multiple myeloma. This finding is particularly significant, as patients with relapsed or refractory myeloma often face limited treatment options. The study provides valuable insights into the potential benefits of this triplet regimen for this challenging patient population.

Navigating the Complexities of Multiple Myeloma

As a healthcare professional, I am committed to providing the best possible care for my patients with multiple myeloma. This study is a testament to the ongoing efforts to develop new and effective treatment options for this complex disease. The promising results of this triplet regimen offer hope for patients who have exhausted other treatment options. It is crucial to continue exploring innovative approaches to combat this challenging disease and improve patient outcomes.

Dr. Camel's Conclusion

Just as a camel navigates the arid landscape, seeking sources of water and nourishment, patients with multiple myeloma often embark on a challenging journey in search of effective treatments. This study sheds light on a promising new regimen that may offer hope and improved outcomes for patients facing this formidable disease. The findings encourage continued research to further optimize treatment strategies and provide the best possible care for those impacted by multiple myeloma.

Date :
  1. Date Completed 2020-06-15
  2. Date Revised 2020-06-15
Further Info :

Pubmed ID

31097405

DOI: Digital Object Identifier

10.1016/S1470-2045(19)30152-4

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.