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Pomalidomide, bortezomib, and dexamethasone for patients with relapsed or refractory multiple myeloma previously treated with lenalidomide (OPTIMISMM): a randomised, open-label, phase 3 trial.
Author: , AndersonKenneth, BeksacMeral, BensmaineAmine, BiyukovTsvetan, DimopoulosMeletios, DoerrThomas, FaconThierry, GalliMonica, LiberatiAnna Marina, LindsayJindriska, O'GormanPeter, OriolAlbert, PelusoTeresa, RichardsonPaul G, RobakPawel, San MiguelJesus, ScheySteve, SchjesvoldFredrik, SemochkinSergey, SonneveldPieter, SunamiKazutaka, WeiselKatja, WhiteDarrell, YuXin, ZakiMohamed
Original Abstract of the Article :
As lenalidomide becomes increasingly established for upfront treatment of multiple myeloma, patients refractory to this drug represent a population with an unmet need. The combination of pomalidomide, bortezomib, and dexamethasone has shown promising results in phase 1/2 trials of patients with rela...See full text at original site
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引用元:
https://doi.org/10.1016/S1470-2045(19)30152-4
データ提供:米国国立医学図書館(NLM)
A Novel Treatment Regimen for Relapsed Multiple Myeloma: Pomalidomide, Bortezomib, and Dexamethasone
The field of [hematology] is dedicated to understanding and treating blood disorders. This research explores a novel treatment regimen for relapsed or refractory multiple myeloma, a type of cancer affecting plasma cells. The authors conducted a randomized, open-label, phase 3 trial to evaluate the efficacy and safety of a combination therapy involving pomalidomide, bortezomib, and dexamethasone in patients previously treated with lenalidomide. The study found that this triplet regimen showed promising results in terms of response rates and overall survival, offering a potential treatment option for patients with lenalidomide-refractory multiple myeloma. The study highlights the potential benefits of this new treatment regimen for a challenging patient population.
A New Hope for Relapsed Multiple Myeloma: A Triplet Regimen Showcases Promise
The promising results of this phase 3 trial suggest that the combination of pomalidomide, bortezomib, and dexamethasone may offer a new and effective treatment option for patients with lenalidomide-refractory multiple myeloma. This finding is particularly significant, as patients with relapsed or refractory myeloma often face limited treatment options. The study provides valuable insights into the potential benefits of this triplet regimen for this challenging patient population.
Navigating the Complexities of Multiple Myeloma
As a healthcare professional, I am committed to providing the best possible care for my patients with multiple myeloma. This study is a testament to the ongoing efforts to develop new and effective treatment options for this complex disease. The promising results of this triplet regimen offer hope for patients who have exhausted other treatment options. It is crucial to continue exploring innovative approaches to combat this challenging disease and improve patient outcomes.
Dr. Camel's Conclusion
Just as a camel navigates the arid landscape, seeking sources of water and nourishment, patients with multiple myeloma often embark on a challenging journey in search of effective treatments. This study sheds light on a promising new regimen that may offer hope and improved outcomes for patients facing this formidable disease. The findings encourage continued research to further optimize treatment strategies and provide the best possible care for those impacted by multiple myeloma.
Date :
- Date Completed 2020-06-15
- Date Revised 2020-06-15
Further Info :
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