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Efficacy and Safety of Flexibly Dosed Esketamine Nasal Spray Combined With a Newly Initiated Oral Antidepressant in Treatment-Resistant Depression: A Randomized Double-Blind Active-Controlled Study.

Author: BajboujMalek, CooperKimberly, DalyElla J, DrevetsWayne C, HoughDavid, LaneRosanne, LimPilar, ManjiHusseini, MazzuccoChristine, MoleroPatricio, PopovaVanina, SheltonRichard C, SinghJaskaran B, ThaseMichael E, TrivediMadhukar, VietaEduard

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study compared the efficacy and safety of switching patients with treatment-resistant depression from an ineffective antidepressant to flexibly dosed esketamine nasal spray plus a newly initiated antidepressant or to a newly initiated antidepressant plus placebo nasal spray.
Paper Details　
Original Abstract of the Article :
About one-third of patients with depression fail to achieve remission despite treatment with multiple antidepressants. This study compared the efficacy and safety of switching patients with treatment-resistant depression from an ineffective antidepressant to flexibly dosed esketamine nasal spray plu...See full text at original site
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引用元：
https://doi.org/10.1176/appi.ajp.2019.19020172

データ提供：米国国立医学図書館（NLM）

Esketamine Nasal Spray: A Novel Approach to Treatment-Resistant Depression

The world of mental health is complex and challenging, especially for those battling treatment-resistant depression. This research explores the efficacy and safety of esketamine nasal spray as a novel treatment option for patients with treatment-resistant depression. Imagine a desert traveler facing a prolonged drought – sometimes, a new source of water is needed to revive the oasis. This study investigates the effectiveness of esketamine nasal spray combined with a newly initiated oral antidepressant compared to a newly initiated antidepressant alone in patients with treatment-resistant depression. The researchers found that the combination of esketamine nasal spray and a new antidepressant showed promising results, suggesting its potential as a valuable tool for managing this challenging condition.

Esketamine Nasal Spray: A Potential Solution for Treatment-Resistant Depression

This study provides encouraging evidence for the efficacy and safety of esketamine nasal spray in treating treatment-resistant depression. The findings suggest that this novel approach, combined with a new antidepressant, can be a valuable tool for managing this challenging condition, offering hope for patients who have not responded to traditional treatments.

Managing Mental Health: A Multi-faceted Approach

This research highlights the importance of exploring novel treatment options for those battling mental health challenges. Just as a desert oasis needs a variety of resources to thrive, managing mental health requires a comprehensive approach, encompassing diverse treatments and therapies. This study emphasizes the need for ongoing research and innovation in the field of mental health, striving to develop effective treatments for all individuals in need.

Dr.Camel's Conclusion

This study investigates the potential of esketamine nasal spray as a novel treatment option for treatment-resistant depression, offering a glimmer of hope for patients who have not responded to traditional treatments.

Date :
  1. Date Completed 2019-12-30
  2. Date Revised 2019-12-30
Further Info :

Pubmed ID

31109201

DOI: Digital Object Identifier

10.1176/appi.ajp.2019.19020172

Related Literature

Article Analysis
・Effects of esketamine nasal spray
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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