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Treatment of cardiac transthyretin amyloidosis: an update.
Author: AimoAlberto, BarisonAndrea, CastiglioneVincenzo, EmdinMichele, FontanaMarianna, GiannoniAlberto, MerliniGiampaolo, PassinoClaudio, PerfettoFederico, RapezziClaudio, SeferovićPetar M, VergaroGiuseppe
Original Abstract of the Article :
Transthyretin (TTR) is a tetrameric protein synthesized mostly by the liver. As a result of gene mutations or as an ageing-related phenomenon, TTR molecules may misfold and deposit in the heart and in other organs as amyloid fibrils. Cardiac involvement in TTR-related amyloidosis (ATTR) manifests ty...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1093/eurheartj/ehz298
データ提供:米国国立医学図書館(NLM)
Treatment of Cardiac Transthyretin Amyloidosis: An Update
In the field of [cardiology], [transthyretin (TTR)-related amyloidosis (ATTR)] is a complex and challenging condition that can lead to heart failure. This review provides an update on the treatment options available for patients with cardiac ATTR, highlighting the advancements in pharmacological therapies that have emerged in recent years. The authors discuss the various approaches to targeting the underlying disease mechanisms and mitigating the consequences of amyloid deposition in the heart.
New Horizons in Cardiac ATTR Treatment
The review highlights the significant advancements in the treatment of [cardiac ATTR], with the emergence of several pharmacological agents that inhibit hepatic synthesis of TTR, stabilize the tetramer, or disrupt fibrils. These therapies offer new hope for patients with this debilitating condition, potentially improving their quality of life and extending their lifespan.
A Multifaceted Approach to Managing Cardiac ATTR
This review emphasizes the importance of a [multifaceted approach] to managing cardiac ATTR. The combination of pharmacological therapies, supportive care, and, in select cases, transplantation can significantly improve patient outcomes. Imagine a caravan traversing a vast and challenging desert, where a combination of resources and strategies is needed to navigate the terrain. This review provides a similar roadmap for navigating the complex landscape of cardiac ATTR treatment, offering a more comprehensive and effective approach to managing this disease.
Dr.Camel's Conclusion
This research underscores the relentless pursuit of innovation in the field of medicine. The development of new and effective treatments for cardiac transthyretin amyloidosis, like finding a hidden oasis in the vast and arid desert, offers a glimmer of hope for patients, providing them with a path towards a healthier and more fulfilling life.
Date :
- Date Completed 2020-10-20
- Date Revised 2021-03-17
Further Info :
Related Literature
English
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