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Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR.

Author: ChenWei, EguchiTadashi, GaoChenlang, GaoQiong, InokiKen, KudoFumitaka, LiDan, RuanBenfang, SahooNirakar, ShaoRong, SuLin, WangShiyi, XuHaoxing, YanXueni, YangJunsheng, YangMeimei, YaoYao, ZhangXiaoli, ZhaoHan

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

Rapamycin, a drug used to treat cancer and neurodegeneration, has been shown to activate TRPML1, a calcium release channel in lysosomes, leading to increased autophagy. This process helps clear damaged cells and may contribute to the drug's neuroprotective and anti-aging effects.
Paper Details　
Original Abstract of the Article :
Rapamycin (Rap) and its derivatives, called rapalogs, are being explored in clinical trials targeting cancer and neurodegeneration. The underlying mechanisms of Rap actions, however, are not well understood. Mechanistic target of rapamycin (mTOR), a lysosome-localized protein kinase that acts as a c...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528971/

データ提供：米国国立医学図書館（NLM）

Rapamycin's Hidden Talent: Activating Lysosomal TRP Channels

This study unveils a new mechanism of action for rapamycin, a drug used to treat cancer and neurodegeneration. It's like discovering a hidden spring in the desert that provides not just water but also a powerful revitalizing force! The researchers found that rapamycin can directly activate a specific type of channel in lysosomes, promoting autophagy, a cellular process crucial for health and longevity.

Rapamycin: A Multifaceted Oasis in the Desert of Disease

This study explores the mechanisms behind rapamycin's therapeutic effects, revealing a previously unknown pathway that involves the activation of lysosomal TRPML1 channels. This is like discovering a hidden wellspring in the desert that can unlock a new source of healing power. The study found that rapamycin's ability to directly activate these channels promotes autophagy, a crucial cellular process for maintaining health and fighting disease.

Rapamycin: A Promise for Health and Longevity

This study suggests that rapamycin's ability to activate TRPML1 channels may contribute to its therapeutic effects in treating cancer and neurodegeneration. It's like discovering a new oasis in the desert, offering a source of rejuvenation and longevity. The study's findings open up new avenues for research and development of therapies that target these lysosomal channels.

Dr. Camel's Conclusion

This research highlights the importance of understanding the intricate workings of cellular pathways to develop new and effective treatments. It's like uncovering a hidden map that reveals the secrets of a desert oasis, guiding us toward a deeper understanding of cellular processes and their role in maintaining health.
Date :
  1. Date Completed 2019-12-16
  2. Date Revised 2022-12-14
Further Info :

Pubmed ID

31112550

DOI: Digital Object Identifier

PMC6528971

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Languages

English

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