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Effects of topical piroxicam and sun filters in actinic keratosis evolution and field cancerization: a two-center, assessor-blinded, clinical, confocal microscopy and dermoscopy evaluation trial.

Author: AgozzinoMarina, ArgenzianoGiuseppe, BianchiLuca, CampioneElena, FranceschiniChiara, GarofaloVirginia, MazzilliSara, MilaniMassimo, RussoTeresa

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This two-center, assessor-blinded, prospective trial evaluated the effect of a topical product containing piroxicam and sun filters (ACTX) on actinic keratosis (AK) lesions. ACTX significantly reduced AK lesion number and improved RCM/dermoscopy severity scores.
Paper Details　
Original Abstract of the Article :
<b>Background:</b> Actinic keratosis (AK) is considered an "in situ" non-melanoma skin cancer induced by ultraviolet chronic exposure. Sunscreen and topical anti-inflammatory agents like diclofenac could improve the evolution of this kind of lesions. A topical product containing piroxicam 0.8% and ...See full text at original site
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引用元：
https://doi.org/10.1080/03007995.2019.1626227

データ提供：米国国立医学図書館（NLM）

A Topical Treatment for Actinic Keratosis

This research delves into the realm of dermatology, specifically focusing on the treatment of Actinic Keratosis (AK), a precancerous skin condition often caused by prolonged exposure to ultraviolet (UV) radiation. The study investigates the efficacy of a topical cream called ACTX, which contains piroxicam and sun filters. The researchers used a two-center, assessor-blinded, prospective trial to evaluate the impact of ACTX on AK lesions. The trial's primary goal was to determine the effectiveness of ACTX in reducing the number of AK lesions and improving the appearance of the affected skin.

Promising Results for Actinic Keratosis

The results of the study were quite encouraging. After six months of treatment with ACTX, there was a significant decrease in the number of AK lesions observed in 90% of the participants. The average number of lesions dropped by 42%, and more than half of the subjects experienced a reduction in lesions exceeding 50%. Furthermore, ACTX was associated with a notable decrease in the severity of AK lesions, as assessed by reflectance confocal microscopy (RCM) and dermoscopy.

Protecting Your Skin from the Sun

These findings suggest that ACTX may be a valuable treatment option for individuals with AK. While the study highlights the potential of ACTX, it's important to remember that sun protection is crucial in preventing the development of AK in the first place. Wearing sunscreen with an SPF of 30 or higher, seeking shade during peak sun hours, and covering exposed skin with clothing are essential steps in safeguarding your skin from the damaging effects of UV radiation.

Dr.Camel's Conclusion

ACTX holds potential as a topical treatment for AK. It's important to consult with a dermatologist to discuss the potential benefits and risks of ACTX. Remember, preventing AK through sun protection is paramount. Think of your skin as a precious desert oasis—it needs care and attention to thrive!

Date :
  1. Date Completed 2020-06-17
  2. Date Revised 2020-06-17
Further Info :

Pubmed ID

31148490

DOI: Digital Object Identifier

10.1080/03007995.2019.1626227

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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