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Successful treatment by prednisolone for interstitial pneumonia associated with anagrelide in a patient with essential thrombocythemia.

Author: KatayamaNaoyuki, MatsumotoTakeshi, MizunoToshiro, NishikawaMasakatsu, OdaHiroyasu, SugimotoYuka, TamaruSatoshi, TonoYasutaka

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Overview

Anagrelide is a cytoreductive agent for essential thrombocythemia with common side effects like anemia and diarrhea. This case report highlights a rare adverse event: severe lung injury leading to hemoptysis.
Paper Details　
Original Abstract of the Article :
Anagrelide is a cytoreductive agent for essential thrombocythemia and its common side effects are anemia, headache, palpitation, diarrhea, and fluid retention. However, severe pulmonary adverse effects are rare. A 66-year-old Japanese man with essential thrombocythemia presented with hemoptysis 2 mo...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6498308/

データ提供：米国国立医学図書館（NLM）

Anagrelide and Interstitial Pneumonia: Navigating a Stormy Desert

Essential thrombocythemia (ET), a rare blood disorder, often requires cytoreductive agents to control platelet levels. Anagrelide, a commonly used drug for ET, is generally well-tolerated, but severe pulmonary adverse effects are rare. This case report, like a camel caravan facing a sudden sandstorm, highlights a case of interstitial pneumonia associated with anagrelide treatment.

A Unexpected Twist in the Desert

The authors describe the case of a 66-year-old man who developed interstitial pneumonia shortly after starting anagrelide therapy for ET. This unexpected complication, while rare, emphasizes the importance of careful monitoring for pulmonary adverse events in patients receiving anagrelide. It's like encountering a sudden detour on a desert journey, requiring a change in course and careful navigation to avoid potential hazards.

The Importance of Early Intervention

The patient's prompt response to discontinuation of anagrelide and initiation of corticosteroids highlights the importance of early intervention for anagrelide-associated interstitial pneumonia. This case serves as a reminder for clinicians to be vigilant and to recognize the potential for this rare but serious adverse event. It's like finding a hidden oasis of knowledge and awareness, guiding clinicians towards prompt and effective interventions.

Dr. Camel's Conclusion

This case report underscores the importance of careful monitoring for pulmonary adverse events in patients receiving anagrelide therapy for essential thrombocythemia. While interstitial pneumonia is a rare complication, its timely recognition and prompt management are crucial for ensuring patient safety and well-being. The authors' report serves as a valuable reminder for clinicians to be vigilant and responsive to potential side effects, particularly those that may be unexpected.
Date :
  1. Date Completed n.d.
  2. Date Revised 2020-10-01
Further Info :

Pubmed ID

31149463

DOI: Digital Object Identifier

PMC6498308

Related Literature

Article Analysis
・Side Effects of anagrelide
SNS
PICO Info
in preparation
Languages

English

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