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Old Drugs, New Delivery Systems in Parkinson's Disease.
Author: GuptaHarsh V, LyonsKelly E, PahwaRajesh
Original Abstract of the Article :
Levodopa is the mainstay of treatment in Parkinson's disease (PD). As the disease progresses, variations in plasma levodopa levels lead to motor fluctuations. The common reasons behind variations in the plasma levels include delayed gastric emptying, small intestinal bacterial overgrowth, protein in...See full text at original site
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引用元:
https://doi.org/10.1007/s40266-019-00682-9
データ提供:米国国立医学図書館(NLM)
New Delivery Systems for Old Drugs: A Promising Approach to Parkinson's Disease
The field of [Neurology] faces the challenge of [managing Parkinson's disease (PD)] and its associated [motor fluctuations]. This research delves into the [development of novel delivery systems] for existing medications, aiming to [improve the efficacy and reduce the side effects] of [levodopa], a cornerstone treatment for [PD]. The authors provide a [comprehensive review] of [emerging delivery options], including [infusion therapy with apomorphine, modified dopamine agonists, various oral formulations of carbidopa/levodopa, inhaled levodopa, intrajejunal infusion of levodopa, and sublingual apomorphine]. They discuss the [advantages, dosage, and adverse effects] of each treatment modality.
Optimizing Levodopa Delivery: A Path to Better Control
This research highlights the importance of [optimizing levodopa delivery] to [improve symptom management and quality of life] in patients with [PD]. The development of [new delivery systems] offers a promising approach to [mitigate the challenges] associated with [oral levodopa administration], such as [fluctuations in plasma levels and gastrointestinal side effects].
Living with Parkinson's Disease: A Journey of Adaptability
This research emphasizes the importance of [working closely with a neurologist] to [find the most effective treatment] for [PD]. [Lifestyle modifications], such as [regular exercise, a balanced diet, and stress management], can also play a crucial role in [managing symptoms and maintaining overall well-being]. This study serves as a beacon of hope for individuals living with [PD], reminding them that [effective treatments] are constantly evolving, offering new avenues for [improving quality of life] and [enhancing overall well-being].
Dr.Camel's Conclusion
This research is like a well-traveled caravan route in the desert, guiding us towards better management of Parkinson's disease. By exploring new ways to deliver existing medications, we can potentially find the right oasis of symptom control and well-being for patients.
Date :
- Date Completed 2019-12-11
- Date Revised 2020-03-09
Further Info :
Related Literature
English
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