Safety and Efficacy of Supratherapeutic Doses of Clobazam.

Author: FreedmanDaniel A, GedelaSatyanarayana, GedelaSravya, GlynnPeter, PatelAnup D, SalvatorAnn

Paper Details 
Original Abstract of the Article :
Clobazam is a commonly used long-acting benzodiazepine approved by the US Food and Drug Administration (FDA) to treat seizures associated with Lennox Gastaut syndrome. The FDA approved maximum dosage of clobazam is 1 mg/kg/d or a total of 40 mg a day. Many providers exceed this dosage but there is l...See full text at original site
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引用元:
https://doi.org/10.1177/0883073819856834

データ提供:米国国立医学図書館(NLM)

Clobazam: Exploring the Safety and Efficacy of Supratherapeutic Doses

Clobazam, a benzodiazepine medication used to treat seizures, has a maximum recommended dosage. However, many healthcare providers exceed this dosage in clinical practice. This study investigated the safety and efficacy of supratherapeutic doses of clobazam in patients with Lennox-Gastaut syndrome, a severe form of epilepsy. The authors conducted a retrospective review of patient data, comparing outcomes in patients receiving supratherapeutic doses to those receiving therapeutic doses. The study found no significant differences in seizure control, healthcare utilization, or side effects between the two groups, suggesting that supratherapeutic doses of clobazam may be safe and effective in certain situations.

Beyond the Limits: Exploring the Safety of Supratherapeutic Doses

The study's findings are like a camel caravan venturing beyond the familiar desert trails, seeking a more effective and safe route. The researchers investigated the safety and efficacy of exceeding the recommended dosage of clobazam, carefully analyzing the potential risks and benefits. The results offer valuable insights into the use of supratherapeutic doses of clobazam, providing evidence to support its potential safety and efficacy.

Optimizing Treatment: Finding the Right Balance for Individual Needs

This study highlights the importance of individualized treatment approaches, particularly for complex conditions like epilepsy. Just as a camel caravan adjusts its pace and strategy based on the terrain, healthcare providers need to carefully consider the specific needs of each patient when determining the appropriate dosage of medications. This study provides valuable information for making informed decisions about clobazam dosage, balancing the potential benefits with the need for safety and efficacy.

Dr. Camel's Conclusion

This study offers a valuable insight into the use of supratherapeutic doses of clobazam, suggesting that it may be a safe and effective option for certain patients. It's like a camel caravan finding a new and efficient route through the desert, leading to a better outcome for the journey.

Date :
  1. Date Completed 2020-09-14
  2. Date Revised 2020-09-14
Further Info :

Pubmed ID

31215313

DOI: Digital Object Identifier

10.1177/0883073819856834

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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