Multiple-dose clinical pharmacology of ACT-541468, a novel dual orexin receptor antagonist, following repeated-dose morning and evening administration.

Author: BrooksSander, DingemanseJasper, MuehlanClemens, ZuikerRob, van GervenJoop

Paper Details 
Original Abstract of the Article :
ACT-541468 is a dual orexin receptor antagonist with sleep-promoting effects in humans. Following entry-into-humans, its pharmacokinetics (PK) including dose-proportionality and accumulation, pharmacodynamics (PD), safety, and tolerability following multiple-ascending oral dose (MAD) administration ...See full text at original site
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引用元:
https://doi.org/10.1016/j.euroneuro.2019.05.009

データ提供:米国国立医学図書館(NLM)

ACT-541468 for Insomnia: A New Oasis in the Desert of Sleeplessness

Imagine insomnia as a relentless sandstorm that keeps you awake all night, preventing you from finding rest and rejuvenation. ACT-541468 is a new medication designed to help people with insomnia, like a special sand-clearing tool that can bring calm and peaceful sleep. This study investigated the safety, effectiveness, and pharmacokinetics of ACT-541468 in healthy volunteers.

The researchers found that ACT-541468 was well-tolerated and had sleep-promoting effects. It worked by blocking the orexin receptors in the brain, which are involved in regulating wakefulness. This is like discovering a hidden oasis that produces a special type of sand that can calm the desert winds and bring about a peaceful night's sleep.

The Desert of Sleep: Finding Rest and Rejuvenation

This study suggests that ACT-541468 could be a promising new treatment for insomnia. It offers hope for individuals struggling to get a good night's sleep, providing a potential oasis in the desert of sleeplessness.

Resting in the Desert: Seeking Help for Insomnia

If you are struggling with insomnia, it's crucial to seek help from a healthcare professional. They can help you determine the underlying cause of your insomnia and recommend the best treatment options for you. It's like finding a skilled desert guide who can help you navigate the complex terrain of sleep disorders and find a path to peaceful slumber.

Dr.Camel's Conclusion

This study provides a glimmer of hope for individuals struggling with insomnia. ACT-541468 offers a potential new avenue for treatment, providing a chance to escape the relentless sandstorms of sleeplessness and find a restful oasis in the desert of night.

Date :
  1. Date Completed 2020-08-10
  2. Date Revised 2020-09-22
Further Info :

Pubmed ID

31221502

DOI: Digital Object Identifier

10.1016/j.euroneuro.2019.05.009

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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