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Rethinking results from the Japanese 23-valent pneumococcal polysaccharide vaccine randomized clinical trial.

Author: GessnerBradford D, JodarLuis, TheilackerChristian

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study reviewed a clinical trial that was used to support the use of the 23-valent pneumococcal polysaccharide vaccine (PPSV23) in adults. The authors argue that the trial had serious flaws that affect its usefulness in evaluating pneumococcal vaccines.
Paper Details　
Original Abstract of the Article :
We review a previously published randomized clinical trial of 23-valent pneumococcal polysaccharide vaccine (PPSV23) that has been used extensively globally to support PPSV23 use among adults. We argue that serious issues with internal and external validity exist that affect the usefulness of these ...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.vaccine.2019.07.040

データ提供：米国国立医学図書館（NLM）

Pneumococcal Vaccine: Re-evaluating the Evidence

The pneumococcal polysaccharide vaccine (PPSV23) is a widely used vaccine for preventing pneumococcal infections. However, this study raises concerns about the validity of a previous clinical trial that has been used to support PPSV23 use in adults. It's like examining a long-standing map of the desert, finding inaccuracies and inconsistencies that need to be addressed.

Scrutinizing the Data

The study points to serious issues with the internal and external validity of the previous trial, raising questions about the reliability of the data and its applicability to the general adult population. This is like finding flaws in a map of the desert, leading researchers to question the accuracy of the information and its ability to guide them safely through the terrain.

A Need for Further Research

The study suggests that further research is needed to evaluate the effectiveness of PPSV23 in the general adult population. It's important to ensure that the maps we use to navigate the desert of medical research are accurate and reliable.

Dr. Camel's Conclusion

This study serves as a reminder that scientific research is an ongoing process. It's like a continuous journey through the desert of knowledge, where we must constantly re-evaluate our assumptions and refine our understanding of the world around us.

Date :
  1. Date Completed 2020-10-06
  2. Date Revised 2021-01-31
Further Info :

Pubmed ID

31327653

DOI: Digital Object Identifier

10.1016/j.vaccine.2019.07.040

Related Literature

Article Analysis
・Effects of pneumococcal polysaccharide vaccine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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