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Natural products with SGLT2 inhibitory activity: Possibilities of application for the treatment of diabetes.

Author: Moradi-MarjanehReyhaneh, PasebanMaryam, SahebkarAmirhossein

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

SGLT2 inhibitors are a new class of drugs for the treatment of type 2 diabetes mellitus (T2DM).
Paper Details　
Original Abstract of the Article :
Diabetes mellitus currently affects as many as 400 million people worldwide, creating a heavy economic burden and stretching health care resources. A dysfunction of glucose homeostasis underlies the disease. Despite advances in the treatment of diabetes, many patients still suffer from complications...See full text at original site
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引用元：
https://doi.org/10.1002/ptr.6421

データ提供：米国国立医学図書館（NLM）

Natural Products: A Potential Source of SGLT2 Inhibitors for Diabetes Treatment

Diabetes mellitus, a chronic metabolic disorder affecting millions worldwide, is a significant public health concern. This review focuses on the potential of natural products as sources of SGLT2 inhibitors, a class of drugs that can effectively lower blood glucose levels.

Natural Products: Exploring Novel SGLT2 Inhibitors

Researchers highlight the growing interest in natural products that can inhibit SGLT2, the principle cotransporter responsible for glucose reabsorption in the kidneys. They discuss the potential of phlorizin, a flavonoid found in apple tree bark, as a lead structure for developing SGLT2 inhibitors. The review also explores other natural product-derived compounds with SGLT2 inhibitory activity.

A Desert Oasis of Natural Remedies

Think of the search for new diabetes treatments as a journey through a vast and unforgiving desert. Natural products, like oases along the way, offer promising sources of novel therapeutic compounds, such as SGLT2 inhibitors.

Dr. Camel's Conclusion

This review provides a comprehensive overview of the potential of natural products as sources of SGLT2 inhibitors for the treatment of diabetes. The review highlights the importance of continued research to explore the therapeutic potential of natural products in managing this challenging condition.

Date :
  1. Date Completed 2019-12-26
  2. Date Revised 2020-01-08
Further Info :

Pubmed ID

31359514

DOI: Digital Object Identifier

10.1002/ptr.6421

SNS
PICO Info
in preparation
Languages

English

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