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Pharmacological Evaluation of Dotinurad, a Selective Urate Reabsorption Inhibitor.

Author: AshizawaNaoki, ChikamatsuNoriko, HagiharaChiharu, HashibaMasamichi, IwanagaTakashi, MatsumotoKoji, MotokiKeisuke, SaitoRyo, SakaiMiku, TaniguchiTetsuya

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Dotinurad is a new uricosuric agent that selectively inhibits URAT1, a transporter involved in uric acid reabsorption, with minimal impact on other urate transporters. In a monkey study, dotinurad effectively lowered plasma urate levels in a dose-dependent manner, more so than benzbromarone. This suggests that dotinurad may be a more effective and selective treatment for hyperuricemia compared to currently available medications.
Paper Details　
Original Abstract of the Article :
The effect of dotinurad [(3,5-dichloro-4-hydroxyphenyl)(1,1-dioxo-1,2-dihydro-3H-1<i>&#955;</i> <sup>6</sup>-1,3-benzothiazol-3-yl)methanone] was compared with that of commercially available uricosuric agents-namely, benzbromarone, lesinurad, and probenecid. Its effect on urate secretion transporter...See full text at original site
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引用元：
https://doi.org/10.1124/jpet.119.259341

データ提供：米国国立医学図書館（NLM）

Dotinurad: A New Hope for Gout Treatment

[Gout] is a painful inflammatory condition caused by the accumulation of uric acid crystals in the joints. This study explores the pharmacological properties of [dotinurad], a novel [urate reabsorption inhibitor], comparing its effects to other uricosuric agents, such as [benzbromarone, lesinurad, and probenecid]. Researchers found that dotinurad is a potent and selective inhibitor of [urate transporter 1 (URAT1)], suggesting it could be an effective treatment for gout with a favorable side effect profile. Further clinical trials are needed to confirm these findings and evaluate the long-term efficacy and safety of dotinurad.

A New Oasis in Gout Treatment: The Promise of Dotinurad

The study found that dotinurad is a potent inhibitor of URAT1, the primary transporter responsible for reabsorbing uric acid in the kidneys. This is like discovering a new oasis in the desert: dotinurad offers a promising new approach for managing gout by reducing uric acid levels in the blood. The study suggests that dotinurad, with its high selectivity for URAT1, could be a valuable addition to the armamentarium for treating gout, offering a potentially more effective and well-tolerated treatment option.

A Journey Towards Effective Gout Management: Hope for the Future

The desert teaches us that patience and persistence are key to success. This study provides a glimpse of hope for those struggling with gout, suggesting that dotinurad could be a valuable new treatment option. However, further research is needed to confirm its efficacy and safety in clinical settings, paving the way for a more effective and personalized approach to managing gout in the future.

Dr.Camel's Conclusion

This study suggests that dotinurad, a novel urate reabsorption inhibitor, could be a promising new treatment for gout. Further clinical trials are needed to confirm its efficacy and safety, but dotinurad offers hope for a more effective and well-tolerated treatment option for those struggling with this painful and debilitating condition.

Date :
  1. Date Completed 2020-04-20
  2. Date Revised 2020-06-25
Further Info :

Pubmed ID

31371478

DOI: Digital Object Identifier

10.1124/jpet.119.259341

Related Literature

Article Analysis
・Effects of lesinurad
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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