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Development of Dexlansoprazole Delayed-Release Capsules, a Dual Delayed-Release Proton Pump Inhibitor.

Author: GradyHaiyan, KukulkaMichael, MulfordDarcy, MurakawaYusuke

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Dexplansoprazole is a proton pump inhibitor (PPI) used to treat heartburn and acid reflux. It is a more advanced version of lansoprazole that is absorbed more quickly and stays in the body longer.
Paper Details　
Original Abstract of the Article :
Proton pump inhibitors (PPIs) are widely used for treating acid-related disorders. For an "ideal PPI," achieving maximal absorption and sustaining pharmacodynamic effects through the 24-h dosing cycle are critical features. Dexlansoprazole offers a relevant case study on how an improved PPI was deve...See full text at original site
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引用元：
https://doi.org/10.1016/j.xphs.2019.07.023

データ提供：米国国立医学図書館（NLM）

Dexlansoprazole: A New Frontier in Proton Pump Inhibitor Therapy

Proton pump inhibitors (PPIs) are widely used to treat acid-related disorders, such as heartburn and ulcers. This research explores the development of dexlansoprazole, a novel PPI with improved pharmacokinetic properties. They discuss the optimization of the lansoprazole molecule to create dexlansoprazole, its stereoselective absorption and metabolism, and the development of a dual delayed-release formulation. This formulation allows for prolonged drug release and sustained therapeutic plasma concentrations compared to conventional lansoprazole formulations.

Dexlansoprazole: A More Effective PPI for Lasting Relief

This research highlights the potential of dexlansoprazole to provide longer-lasting relief from acid-related disorders. Its unique dual delayed-release formulation ensures sustained therapeutic concentrations, potentially leading to fewer symptoms and improved quality of life for patients.

Dexlansoprazole: A Beacon of Hope for Acid Reflux

This research offers hope for individuals struggling with acid reflux and related conditions. Dexlansoprazole's improved pharmacokinetic properties could lead to more effective and convenient treatment options, allowing individuals to manage their symptoms with greater ease.

Dr.Camel's Conclusion

This research is a testament to the ongoing quest for better and more effective treatments. Dexlansoprazole, like a refreshing oasis in the desert of acid-related disorders, offers a promising new approach to managing these conditions.

Date :
  1. Date Completed 2020-09-08
  2. Date Revised 2020-09-08
Further Info :

Pubmed ID

31386865

DOI: Digital Object Identifier

10.1016/j.xphs.2019.07.023

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Languages

English

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