Paper Details

  1. Home
  2. Paper Details

Hedgehog pathway inhibition as a therapeutic target in acute myeloid leukemia.

Author: BewersdorfJan Philipp, BodduPrajwal C, ShallisRory M, ZeidanAmer M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

The Hedgehog (HH) pathway plays a crucial role in both embryogenesis and adult stem cell maintenance. This review explores the role of the HH pathway in hematopoiesis, the pathology of acute myeloid leukemia (AML), and the rationale for targeting the HH pathway in AML therapy. The review discusses the first approved HH pathway inhibitor for AML (glasdegib) and ongoing clinical trials with other HH pathway inhibitors.
Paper Details　
Original Abstract of the Article :
<b>Introduction</b>: The Hedgehog (HH) pathway constitutes a collection of signaling molecules which critically influence embryogenesis. In adults, however, the HH pathway remains integral to the proliferation, maintenance, and apoptosis of adult stem cells including hematopoietic stem cells. <b>Ar...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1080/14737140.2019.1652095

データ提供：米国国立医学図書館（NLM）

Targeting the Hedgehog Pathway in Acute Myeloid Leukemia: A New Oasis in the Desert of Cancer Treatment

Acute myeloid leukemia (AML) is a serious blood cancer, and finding effective treatment options is a crucial challenge. This review examines the potential of targeting the Hedgehog (HH) pathway as a therapeutic strategy for AML. The researchers discuss the role of the HH pathway in normal hematopoiesis and its involvement in AML development. They highlight the rationale for using HH pathway inhibitors in combination with conventional therapies and review the current clinical trial data. The authors suggest that targeting the HH pathway holds promise as a potential new avenue for treating AML, but further research is needed to fully understand its potential and optimize its use.

A New Path in the Desert of AML Treatment

This review highlights the exciting potential of HH pathway inhibition as a new therapeutic strategy for AML. The data suggest that targeting this pathway could effectively combat the disease and improve treatment outcomes. This research offers a glimmer of hope in the desert of AML treatment, providing a new path towards effective therapies and improved survival rates for patients.

A Promise for a Brighter Future

The journey of fighting cancer is often a challenging and arduous one. This review provides a ray of hope, highlighting the potential of HH pathway inhibition to offer new treatment options for AML. The research emphasizes the need for continued investigation and clinical trials to further explore the efficacy and safety of this approach, offering a promise for a brighter future for patients battling AML.

Dr.Camel's Conclusion

This review explores the exciting potential of HH pathway inhibition as a new therapeutic strategy for AML. It underscores the need for further research to optimize its use and offers a promise for a brighter future for patients battling AML.

Date :
  1. Date Completed 2020-03-20
  2. Date Revised 2020-03-20
Further Info :

Pubmed ID

31422721

DOI: Digital Object Identifier

10.1080/14737140.2019.1652095

Related Literature

Article Analysis
・Effects of glasdegib
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.