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Synergistic effects of PRIMA-1<sup>Met</sup> (APR-246) and 5-azacitidine in <i>TP53</i>-mutated myelodysplastic syndromes and acute myeloid leukemia.
Author: AdesLionel, AubinPhilippe, BallyCecile, CassinatBruno, DrevonLouis, FenauxPierre, GiraudierStephane, Lehmann-CheJacqueline, LyPierre, MaslahNabih, MiekoutimaElsa, NaouiNadia, PartoucheNicolas, RahméRamy, SalomaoNorman, SchlageterMarie-Helene, VergerEmmanuelle
Original Abstract of the Article :
Myelodysplastic syndromes and acute myeloid leukemia with <i>TP53</i> mutations are characterized by frequent relapses, poor or short responses, and poor survival with the currently available therapies including chemotherapy and 5-azacitidine (AZA). PRIMA-1<sup>Met</sup>(APR-246,APR) is a methylated...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271596/
データ提供：米国国立医学図書館（NLM）
Synergistic Effects of PRIMA-1Met and 5-azacitidine in TP53-Mutated Myelodysplastic Syndromes and Acute Myeloid Leukemia
Myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) are complex diseases that affect the blood. These conditions often involve mutations in the TP53 gene, which leads to challenges in treatment. This study focuses on the potential of using PRIMA-1Met (APR-246) in combination with 5-azacitidine (AZA) to address these mutations.
The researchers investigated the synergistic effects of APR and AZA in TP53-mutated MDS/AML cells. They found that low doses of APR, either alone or in combination with AZA, could reactivate the p53 pathway and induce apoptosis. This suggests that APR might be a promising addition to conventional treatments for TP53-mutated MDS/AML.
A Potential Breakthrough in TP53-Mutated MDS/AML Treatment
This study highlights a potential breakthrough in the treatment of TP53-mutated MDS/AML. The researchers identified a synergistic effect of APR and AZA, suggesting that combining these drugs could be a more effective strategy for treating these challenging diseases. The data suggests that APR + AZA may be a more potent approach than either drug alone, leading to potential improvements in patient outcomes.
Hope for Patients with TP53-Mutated MDS/AML
This study offers a ray of hope for patients with TP53-mutated MDS/AML. The discovery of a synergistic effect between APR and AZA is a significant development that could lead to improved treatment options. This research highlights the importance of ongoing research in finding new and better ways to treat these complex diseases.
Dr.Camel's Conclusion
Just as a camel adapts to the desert environment, scientists are constantly searching for ways to adapt treatment strategies for these challenging diseases. This study offers a promising new approach to treating TP53-mutated MDS/AML, showcasing the potential of combination therapy for improved outcomes.
Date :
- Date Completed 2021-04-27
- Date Revised 2021-11-24
Further Info :
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