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Development of an optimized avanafil-loaded invasomal transdermal film: Ex vivo skin permeation and in vivo evaluation.

Author: AhmedOsama A A, Badr-EldinShaimaa M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the development of optimized nanosized avanafil (AVA) invasomes for enhanced transdermal delivery. The optimized invasomal film showed enhanced ex vivo permeation and a four-fold increase in relative bioavailability compared to the raw AVA film.
Paper Details　
Original Abstract of the Article :
Avanafil (AVA) is a recent FDA approved selective phosphodiesterase type 5 inhibitor used for oral treatment of erectile dysfunction. The oral bioavailability of the drug is challenged by its reduced water solubility, considerable presystemic metabolism, and altered absorption in the presence of foo...See full text at original site
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引用元：
https://doi.org/10.1016/j.ijpharm.2019.118657

データ提供：米国国立医学図書館（NLM）

Optimized Avanafil-Loaded Invasomal Transdermal Film

Erectile dysfunction, like a mirage in a vast desert, can leave men feeling lost and frustrated. This study, much like a team of explorers searching for a hidden oasis of relief, investigates the potential of a novel transdermal film loaded with avanafil (AVA), a medication used to treat erectile dysfunction.

A New Route to Relief

This study, like a cleverly constructed canal guiding water through a parched desert, explores a new approach to delivering AVA for the treatment of erectile dysfunction. The researchers develop a transdermal film loaded with AVA invasomes, seeking to improve the drug's bioavailability and reduce its systemic side effects. The study's findings demonstrate the potential of this novel delivery system to provide a more effective and safe treatment option for men with erectile dysfunction.

A Smoother Journey Through the Desert

This study, like a well-maintained camel caravan traversing a vast and challenging desert, highlights the potential of optimized drug delivery systems to improve patient outcomes. The researchers demonstrate that the AVA invasomal film enhances drug permeation and bioavailability, potentially leading to more effective treatment and fewer side effects. This innovative approach could significantly improve the journey through the desert of erectile dysfunction, offering a smoother and more comfortable experience for patients.

Dr.Camel's Conclusion

This study serves as a beacon of hope in the desert of erectile dysfunction research, offering a novel and promising approach to drug delivery. The researchers' findings suggest that the AVA invasomal film could provide a more effective and safe treatment option for men struggling with this condition. This innovative approach has the potential to transform the landscape of erectile dysfunction treatment, making the journey through the desert a bit smoother and more rewarding for patients.
Date :
  1. Date Completed 2020-02-12
  2. Date Revised 2020-02-12
Further Info :

Pubmed ID

31491483

DOI: Digital Object Identifier

10.1016/j.ijpharm.2019.118657

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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