Mechanisms of Non-coenzyme Action of Thiamine: Protein Targets and Medical Significance.

Author: AleshinV A, BunikV I, MkrtchyanG V

Paper Details 
Original Abstract of the Article :
Thiamine (vitamin B1) is a precursor of the well-known coenzyme of central metabolic pathways thiamine diphosphate (ThDP). Highly intense glucose oxidation in the brain requires ThDP-dependent enzymes, which determines the critical significance of thiamine for neuronal functions. However, thiamine c...See full text at original site
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引用元:
https://doi.org/10.1134/S0006297919080017

データ提供:米国国立医学図書館(NLM)

Thiamine: Beyond Its Well-Known Coenzyme Role

Thiamine, also known as vitamin B1, is a vital nutrient essential for many bodily functions. This research delves into the multifaceted nature of thiamine, exploring its actions beyond its well-known role as a coenzyme. The authors discuss the non-coenzyme mechanisms of thiamine action, including its interaction with various proteins and its potential implications for health. The study highlights the growing understanding of thiamine's diverse roles in the body, including its influence on neurotransmission, gene expression, and metabolic processes. Imagine a camel traversing a vast desert, its survival depends on a complex interplay of internal systems and environmental factors. Similarly, thiamine plays a critical role in maintaining our health and well-being, and its actions extend beyond its traditional coenzyme function.

Thiamine: A Multifaceted Nutrient with Diverse Roles

This research expands our understanding of thiamine's diverse functions. The discovery of thiamine's non-coenzyme actions provides valuable insights into its potential role in regulating various biological processes, including neurotransmission, gene expression, and metabolic pathways.

Thiamine: A Vital Nutrient for Overall Health

This research underscores the importance of thiamine for maintaining overall health and well-being. Ensuring adequate thiamine intake is crucial for supporting neurological function, gene expression, and metabolic processes. Just as a camel relies on water and nutrients to survive the harsh desert, we need thiamine to maintain our own vital functions and thrive.

Dr. Camel's Conclusion

This research takes us on a journey beyond the traditional understanding of thiamine. The study highlights the multifaceted nature of this vital nutrient, revealing its diverse roles in the body and its importance for maintaining overall health. It emphasizes the need for further exploration of thiamine's non-coenzyme actions, which could lead to new insights into its therapeutic potential.

Date :
  1. Date Completed 2019-12-11
  2. Date Revised 2019-12-17
Further Info :

Pubmed ID

31522667

DOI: Digital Object Identifier

10.1134/S0006297919080017

Related Literature

SNS
PICO Info
in preparation
Languages

English

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