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Effects of changes in brain 5-HT activity on indicators of cortical arousal.

Author: NetterP, RammsayerT

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Fluoxetine and ritanserin produced opposite effects on cortical arousal in 24 healthy subjects, with fluoxetine increasing and ritanserin decreasing critical flicker fusion frequency.
Paper Details　
Original Abstract of the Article :
Clinical studies on fluoxetine have reported occasional symptoms of increased fatigue in depressed patients. On the other hand, experimental studies in healthy subjects have demonstrated evidence for fluoxetine-induced increases in cortical arousal. The present placebo-controlled study with 24 healt...See full text at original site
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引用元：
https://doi.org/10.1097/00004850-198807000-00004

データ提供：米国国立医学図書館（NLM）

Fluoxetine's Impact on Cortical Arousal: A Placebo-Controlled Study

This study examines the effects of the antidepressant fluoxetine on cortical arousal, a fundamental process that influences our level of alertness and responsiveness. Researchers conducted a controlled experiment involving 24 healthy individuals, comparing the effects of fluoxetine to a placebo. They measured various indicators of cortical arousal, including flicker fusion frequency, time perception, and self-reported alertness levels. Fluoxetine was found to slightly increase flicker fusion frequency, while ritanserin, a 5HT2 receptor blocker, significantly decreased it. Both drugs slightly improved time perception, but both fluoxetine and ritanserin significantly reduced self-ratings of alertness and energy, leading to increased fatigue. This research provides valuable information about the impact of fluoxetine on cortical arousal, highlighting its potential for both stimulating and inhibiting effects, depending on the specific measures considered.

Fluoxetine's Dual Role: Both Activator and Inhibitor

Fluoxetine's ability to both stimulate and inhibit cortical arousal is like the ebb and flow of the tides. It can both energize and calm depending on the context. This complex interplay might explain why some individuals experience increased fatigue while others feel more alert when taking fluoxetine. This study underscores the importance of individual variability in drug responses.

Fluoxetine's Potential Impact on Daily Life

The findings suggest that fluoxetine could potentially affect daily activities, such as driving or working, depending on the individual's response. It's essential for individuals taking fluoxetine to be aware of these potential effects and to work closely with their healthcare providers to monitor their responses and adjust treatment accordingly.

Dr.Camel's Conclusion

This study reminds us that even well-established drugs can have nuanced and sometimes surprising effects on our brains. Fluoxetine's impact on cortical arousal is like a desert mirage: it appears to be both stimulating and inhibiting, depending on the specific aspects of arousal we measure. Further research is needed to understand these complexities and develop individualized approaches to optimize treatment for each patient.

Date :
  1. Date Completed 1991-01-29
  2. Date Revised 2019-10-22
Further Info :

Pubmed ID

3155282

DOI: Digital Object Identifier

10.1097/00004850-198807000-00004

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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