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Effects of 26 Recombinant CYP3A4 Variants on Brexpiprazole Metabolism.

Author: CaiJian-Pin, ChenBingbing, ChenDaoxing, HuGuo-Xin, WangShuanghu, WenJian, ZhangBowen, ZhangXiao-Dan

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Brexpiprazole, a new atypical antipsychotic, is metabolized by CYP3A4, an enzyme with genetic variations that can lead to unpredictable drug responses. This study investigated the effects of 26 CYP3A4 variants on brexpiprazole metabolism, revealing significant variations in enzymatic activity. This information is crucial for predicting individual responses to brexpiprazole and optimizing treatment strategies.
Paper Details　
Original Abstract of the Article :
As a new atypical antipsychotic, brexpiprazole is primarily metabolized by cytochrome P450 3A4 (CYP3A4). However, genetic polymorphisms in CYP3A4 cause wide variability in individuals' responses to brexpiprazole, leading to unpredictable adverse side effects or even therapeutic failure. The present ...See full text at original site
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引用元：
https://doi.org/10.1021/acs.chemrestox.9b00186

データ提供：米国国立医学図書館（NLM）

Effects of 26 Recombinant CYP3A4 Variants on Brexpiprazole Metabolism

Brexpiprazole, an atypical antipsychotic, is metabolized by cytochrome P450 3A4 (CYP3A4). This study investigates the effects of various CYP3A4 genetic variants on brexpiprazole metabolism. The authors examined the enzymatic activity of 26 recombinant CYP3A4 variants in vitro, comparing their ability to metabolize brexpiprazole to the wild-type enzyme. They discovered that [主要な発見] This study provides valuable insights into the genetic variability in brexpiprazole metabolism and could help guide clinicians in optimizing drug dosages and minimizing adverse effects.

CYP3A4 Variants and Drug Metabolism: A Personalized Approach

This study emphasizes that [社会的な意義] The authors' findings highlight the need for personalized medicine approaches in drug therapy, considering genetic variations that can significantly influence drug metabolism and response.

Brexpiprazole and CYP3A4: A Complex Interaction

This study demonstrates that [健康的なベネフィットもしくはリスク] It's essential to discuss your family history and any relevant genetic factors with your doctor before starting brexpiprazole treatment. This information can help your doctor make informed decisions about appropriate dosage and potential side effects.

Dr.Camel's Conclusion

Imagine the human body as a complex desert ecosystem, with various enzymes playing essential roles in metabolizing medications. This study, like a desert explorer meticulously mapping the terrain, reveals the intricate relationship between CYP3A4 variants and brexpiprazole metabolism. It's a reminder that even seemingly subtle variations in our genes can profoundly impact how our bodies process medications. This research emphasizes the need for personalized medicine approaches to ensure safe and effective drug therapy.

Date :
  1. Date Completed 2021-01-21
  2. Date Revised 2021-01-21
Further Info :

Pubmed ID

31560202

DOI: Digital Object Identifier

10.1021/acs.chemrestox.9b00186

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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