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M1 muscarinic receptor is a key target of neuroprotection, neuroregeneration and memory recovery by i-Extract from Withania somnifera.
Author: GuptaRicha, KhannaVinay K, KonarArpita, LahiriDebomoy K, MaloneyBryan, ShuklaRajendra K, ThakurMahendra K, WadhwaRenu
Original Abstract of the Article :
Memory loss is one of the most tragic symptoms of Alzheimer's disease. Our laboratory has recently demonstrated that 'i-Extract' of Ashwagandha (Withania somnifera) restores memory loss in scopolamine (SC)-induced mice. The prime target of i-Extract is obscure. We hypothesize that i-Extract may prim...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769020/
データ提供:米国国立医学図書館(NLM)
Ashwagandha: A Potential Oasis in the Desert of Memory Loss
The world of [Alzheimer's disease] is a vast and often unforgiving desert, where memory loss can be a devastating symptom. This study, like a determined explorer seeking a hidden oasis, investigates the potential of [i-Extract from Withania somnifera (Ashwagandha)] in restoring memory function. Researchers conducted a series of experiments to identify the key targets of [i-Extract] and elucidate its mechanisms of action.
Unlocking the Secrets of Memory Restoration
The findings reveal that [i-Extract] primarily targets the [M1 muscarinic acetylcholine receptor], a key player in regulating [memory processes]. This discovery sheds light on the potential of [Ashwagandha] as a therapeutic agent for [cognitive disorders]. The study demonstrates that [i-Extract] promotes [dendritic formation and growth], suggesting its role in enhancing [neuronal connectivity].
A Glimpse of Hope in the Desert
This study offers a beacon of hope for those seeking ways to combat [memory loss]. The findings suggest that [Ashwagandha] holds promise as a natural remedy for [cognitive decline], potentially offering a valuable tool for managing [Alzheimer's disease] and other neurodegenerative disorders. Further research is needed to fully understand its therapeutic potential and optimize its use.
Dr. Camel's Conclusion
This study provides compelling evidence for the potential of Ashwagandha as a natural remedy for memory loss. By targeting the M1 muscarinic acetylcholine receptor and promoting dendritic growth, it offers a promising approach to combating cognitive decline. Further research is crucial to validate its therapeutic potential and develop effective strategies for its use.
Date :
- Date Completed 2020-11-02
- Date Revised 2021-01-10
Further Info :
Related Literature
English
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