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Efficacy, Safety, and Predictors of Direct-acting antivirals in Hepatitis C Virus Patients with Heterogeneous Liver Diseases.

Author: CesconMatteo, De PaceVanessa, GalliSilvia, MaggiFabrizio, MorelliMaria Cristina, PistelloMauro, RavaioliMatteo, ReMaria Carla, VeroVittoria

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study evaluated the safety, efficacy, and predictor factors of sustained virological response (SVR) after 24 weeks of direct-acting antiviral (DAA) therapy in hepatitis C virus patients with various stages of hepatic disease. The DAAs were highly effective, with SVR rates ranging from 75% to 100%. A Model for End-Stage Liver Disease score <10 and alanine aminotransferase ≤20 U/L at week 8 were positive predictors of SVR.
Paper Details　
Original Abstract of the Article :
Safety, efficacy, and predictor factors of sustained-virological-response after 24 weeks of new direct-acting antivirals were evaluated in hepatitis C virus patients with different stages of hepatic disease. 260 patients, median age 60 years, of whom 48.1% cirrhotics, 17.7% liver transplant recipien...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/31609453

データ提供：米国国立医学図書館（NLM）

Direct-Acting Antivirals for Hepatitis C: Efficacy and Safety in Diverse Liver Disease

Hepatitis C virus (HCV) infection is a global health concern, and the development of direct-acting antivirals (DAAs) has revolutionized its treatment. This study investigates the efficacy and safety of DAAs in HCV patients with various stages of liver disease, including cirrhosis and liver transplant recipients. Researchers analyzed data from 260 patients treated with different DAA regimens and found that DAAs were highly effective in achieving sustained virological response (SVR) across diverse patient populations, with the highest SVR rates observed in patients with genotype 1b HCV. The study also identified predictors of SVR, including specific liver function parameters.

DAAs Offer Hope for Diverse Patient Populations

This study provides encouraging evidence for the efficacy and safety of DAAs in treating HCV infection across diverse patient populations, including those with advanced liver disease. The high SVR rates observed in this study suggest that DAAs can effectively eliminate HCV infection, even in individuals with significant liver damage. This is a major advancement in HCV treatment, offering hope for patients who previously had limited treatment options.

Understanding Predictors of SVR

The study identifies important predictors of SVR, including specific liver function parameters like Model-for-End-Liver-Disease (MELD) score and alanine aminotransferase (ALT) levels. This information can help clinicians tailor treatment strategies to maximize the chances of achieving SVR in HCV patients. By identifying these predictors, healthcare providers can better manage HCV infection and improve patient outcomes.

Dr. Camel's Conclusion

This research, like a camel caravan bringing vital supplies to a desert oasis, provides crucial insights into the efficacy and safety of DAAs in treating HCV infection. The high SVR rates observed in this study offer hope for patients with diverse liver disease, while the identification of SVR predictors empowers healthcare providers to optimize treatment strategies and improve patient outcomes.

Date :
  1. Date Completed 2019-12-06
  2. Date Revised 2021-12-04
Further Info :

Pubmed ID

31609453

DOI: Digital Object Identifier

496N114

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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