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Lipoprotein(a) and Atherosclerotic Cardiovascular Disease: Current Understanding and Future Perspectives.

Author: GuoY G, LinL M, WuM F, WuY, XuK Z, YuJ

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review highlights the importance of Lp(a) as a risk factor for ASCVD and the need for its measurement in specific patient populations. New therapeutic approaches, such as IONIS-APO(a)-LRx, hold promise for reducing Lp(a) levels and improving cardiovascular health.
Paper Details　
Original Abstract of the Article :
PURPOSE: To review current knowledge of elevated lipoprotein(a) [Lp(a)] levels in relation to atherosclerotic cardiovascular disease (ASCVD) and discuss their potential use as biomarkers and therapeutic approaches in clinical practice. METHODS: We summarized the current understanding and recent adv...See full text at original site
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引用元：
https://doi.org/10.1007/s10557-019-06906-9

データ提供：米国国立医学図書館（NLM）

Lipoprotein(a) and Atherosclerotic Cardiovascular Disease: A Complex Connection

This review provides a comprehensive overview of lipoprotein(a) [Lp(a)], a specific type of lipoprotein associated with an increased risk of atherosclerotic cardiovascular disease (ASCVD). The authors delve into the structure, metabolism, and atherogenic mechanisms of Lp(a), highlighting its proatherogenic, proinflammatory, and potentially prothrombotic properties. The authors also discuss the importance of Lp(a) measurement in identifying individuals at high risk for ASCVD and discuss current and future therapeutic approaches for lowering Lp(a) levels.

A New Frontier: Targeting Lp(a) for Cardiovascular Health

The review emphasizes the importance of Lp(a) as a potential target for preventing and treating ASCVD. The authors highlight the need for more effective and targeted therapies to lower Lp(a) levels, particularly in individuals at high risk. This research is like discovering a hidden oasis in the desert, offering a new avenue for improving cardiovascular health.

Hope on the Horizon: A Journey Towards Better Cardiovascular Health

The review provides a comprehensive overview of Lp(a) and its role in cardiovascular health. The authors highlight the importance of ongoing research to develop more effective therapies for lowering Lp(a) levels and ultimately improving cardiovascular health.

Dr.Camel's Conclusion

This comprehensive review provides valuable insights into lipoprotein(a) [Lp(a)] and its role in atherosclerotic cardiovascular disease (ASCVD). The authors highlight the importance of Lp(a) measurement, the need for more effective therapies, and the ongoing research efforts to better understand and manage this complex risk factor.

Date :
  1. Date Completed 2020-06-03
  2. Date Revised 2020-06-03
Further Info :

Pubmed ID

31655942

DOI: Digital Object Identifier

10.1007/s10557-019-06906-9

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English

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