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A Meta-Analysis of Pregnancy Outcomes With Levothyroxine Treatment in Euthyroid Women With Thyroid Autoimmunity.

Author: HouNingning, LiuYongping, MaLin, SunJinhong, SunXiaodong, WangHongsheng

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Levothyroxine (LT4) supplementation in euthyroid women with thyroid autoimmunity (TAI) did not improve pregnancy outcomes, but individualized dosages and early intervention may reduce miscarriage and preterm birth rates.
Paper Details　
Original Abstract of the Article :
CONTEXT: Thyroid autoimmunity (TAI), the most common cause of (sub)clinical hypothyroidism, is associated with adverse pregnancy outcomes. The benefits of levothyroxine (LT4) intervention in women with TAI remain controversial. OBJECTIVE: The purpose of this analysis is to determine the effect of L...See full text at original site
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引用元：
https://doi.org/10.1210/clinem/dgz217

データ提供：米国国立医学図書館（NLM）

Levothyroxine for Thyroid Autoimmunity: A Complex Picture

Thyroid autoimmunity is a common condition that can have significant implications for pregnancy outcomes. This meta-analysis examines the effects of levothyroxine (LT4) treatment in euthyroid women with thyroid autoimmunity.

Navigating the Uncertainties of LT4 Treatment

The results of this meta-analysis are somewhat mixed, highlighting the complexities of LT4 treatment for thyroid autoimmunity during pregnancy. The authors found that LT4 may have some benefits, but the optimal dosage and timing of treatment remain unclear.

Individualized Treatment Strategies

This research emphasizes the need for individualized treatment strategies for women with thyroid autoimmunity during pregnancy. The optimal approach may vary depending on factors such as the severity of the condition, the stage of pregnancy, and individual patient characteristics.

Dr.Camel's Conclusion

LT4 treatment for thyroid autoimmunity during pregnancy is a delicate balancing act, like navigating a shifting sand dune. More research is needed to optimize treatment strategies and ensure the best possible outcomes for both mother and baby.

Date :
  1. Date Completed 2021-01-04
  2. Date Revised 2021-01-04
Further Info :

Pubmed ID

31760420

DOI: Digital Object Identifier

10.1210/clinem/dgz217

Related Literature

Article Analysis
・Effective treatment of hypothyroidism
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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