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Metabolism of thioridazine in the elderly.

Author: CohenB M, SommerB R

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Elderly patients showed higher serum concentrations of thioridazine and its metabolites, and experienced more frequent and severe side effects compared to younger adults after a single dose of thioridazine.
Paper Details　
Original Abstract of the Article :
Metabolism of drugs may change with age. Yet, there are few studies that provide data to help define appropriate doses of neuroleptic drugs in the treatment of the elderly. To address this issue, we determined serum concentrations of thioridazine and its active metabolites, mesoridazine and sulforid...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/3183071

データ提供：米国国立医学図書館（NLM）

Thioridazine: A Tale of Two Age Groups

This research delves into the fascinating world of [pharmacokinetics] and its impact on the [elderly]. The study investigates the [metabolism] of [thioridazine], a commonly prescribed [neuroleptic drug], in [young adults] and [elderly patients] after a single dose. The researchers compared the serum concentrations of [thioridazine and its metabolites] in both groups, revealing significant differences in how the drug is processed.

Age and Drug Metabolism

The research revealed that [elderly patients] metabolize [thioridazine] differently than [young adults], leading to higher serum concentrations and potentially increased [side effects]. This is akin to a camel navigating a desert with shifting sands. The elderly might require a different approach to drug therapy, just as a camel adjusts its travel route based on the changing environment.

Tailoring Drug Therapy

This study provides valuable insights into the importance of considering [age] when prescribing [neuroleptic drugs]. It highlights the need for careful [dose adjustment] and monitoring to ensure safe and effective treatment in the elderly.

Dr.Camel's Conclusion

This research emphasizes the crucial role of [age] in drug metabolism. It highlights the need for individualized [drug therapy] to account for the unique needs of the elderly. Further research is necessary to optimize [neuroleptic drug] therapy for this population and ensure safe and effective treatment.
Date :
  1. Date Completed 1988-12-09
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

3183071

DOI: Digital Object Identifier

3183071

Related Literature

Article Analysis
・Side Effects of mesoridazine
SNS
PICO Info
in preparation
Languages

English

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