Ranolazine may exert its beneficial effects by increasing myocardial adenosine levels.

Author: AlkayedNabil J, CaoZhiping, DavisCatherine M, KaulSanjiv, LeD Elizabeth, LiuLijuan, NagarajanShanthi, NugentMatthew, ScottKristin L Lyon, WeiKevin, ZhaoYan

Paper Details 
Original Abstract of the Article :
We hypothesized that ranolazine-induced adenosine release is responsible for its beneficial effects in ischemic heart disease. Sixteen open-chest anesthetized dogs with noncritical coronary stenosis were studied at rest, during dobutamine stress, and during dobutamine stress with ranolazine. Six add...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424540/

データ提供:米国国立医学図書館(NLM)

Ranolazine: A Potential Adenosine Booster for Heart Health

Ranolazine, a drug used to treat angina pectoris, is known to have cardioprotective effects. This study investigates the potential mechanism behind these effects, focusing on the role of adenosine. The researchers conducted experiments in dogs with coronary stenosis and in cultured cells, measuring adenosine levels and assessing myocardial function. Their findings reveal that ranolazine increases adenosine levels in the heart, both at rest and during stress, suggesting that this mechanism might contribute to its beneficial effects in ischemic heart disease.

Adenosine: A Key Player in Ranolazine's Cardioprotective Effects

This research sheds light on a potential mechanism by which ranolazine exerts its cardioprotective effects. The study highlights the crucial role of adenosine in mediating these benefits, providing further understanding of how this drug works at a molecular level. This discovery opens new avenues for exploring the therapeutic potential of modulating adenosine levels in treating ischemic heart disease.

Protecting Your Heart: Exploring Adenosine's Role

Imagine a desert where the heart is like a fragile oasis, vulnerable to the harshness of ischemia. Ranolazine, like a wellspring of adenosine, emerges as a potential protector of this vital organ. This research underscores the importance of understanding the intricate interplay between adenosine and cardiovascular health, opening new avenues for developing targeted therapies to enhance heart health.

Dr. Camel's Conclusion

Imagine a desert where the heart, like a precious oasis, needs protection from the scorching sun of ischemia. Ranolazine, like a hidden wellspring of adenosine, emerges as a potential life-saver. This study unveils the potential of adenosine to enhance heart health, encouraging us to explore the power of this vital molecule in protecting our most precious organ.

Date :
  1. Date Completed 2020-05-11
  2. Date Revised 2023-07-11
Further Info :

Pubmed ID

31834840

DOI: Digital Object Identifier

PMC8424540

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English

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